RNF43 Protein (Fc Tag)

N° du produit ABIN7490978

Détail du produit

Antigène: RNF43 (Ring Finger Protein 43 (RNF43))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette RNF43 protéine est marqué à la Fc Tag.

Fonction: Recombinant human RNF43 protein with C-terminal human Fc tag

Specificité: RNF43 (Glu43-Tyr197) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: RNF43 (Ring Finger Protein 43 (RNF43))

Autre désignation: RNF43 (RNF43 Produits)

Synonymes: RNF124 Protein, URCC Protein, 4732452J19Rik Protein, RGD1305204 Protein, ring finger protein 43 Protein, RNF43 Protein, Rnf43 Protein

Sujet: RNF124, SSPCS, URCC
Description: The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Poids moléculaire: predicted molecular mass of 39.4 kDa after removal of the signal peptide. The apparent molecular mass of RNF43-hFc is 40-70 kDa due to glycosylation.

UniProt: Q68DV7

Pathways: Signalisation WNT