PBK Protein (AA 1-322) (His tag)

N° du produit ABIN7504501

Détail du produit

Antigène: PBK (PDZ Binding Kinase (PBK))

Type de proteíne: Recombinant

Attributs du protein: AA 1-322

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette PBK protéine est marqué à la His tag.

Fonction: Human PBK/TOPK Protein

Séquence: Met1-Val322

Attributs du produit: Recombinant Human PBK/TOPK Protein is expressed from Baculovirus-Insect Cells with His tag at the C-terminus.It contains Met1-Val322.

Pureté: > 95 % as determined by Tris-Bis PAGE

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: PBK (PDZ Binding Kinase (PBK))

Autre désignation: PBK (PBK Produits)

Synonymes: PBK Protein, topk Protein, CT84 Protein, Nori-3 Protein, SPK Protein, TOPK Protein, 2810434B10Rik Protein, AW538537 Protein, D14Ertd732e Protein, zgc:92050 Protein, PDZ binding kinase Protein, PDZ binding kinase L homeolog Protein, PBK Protein, pbk Protein, Pbk Protein, pbk.L Protein

Sujet: T-lymphokine-activated killer cell-originated protein kinase (TOPK, also known as PDZ-binding kinase or PBK) plays a crucial role in cell cycle regulation and mitotic progression. Abnormal overexpression or activation of TOPK has been observed in many cancers, including colorectal cancer, triple-negative breast cancer, and melanoma, and it is associated with increased development, dissemination, and poor clinical outcomes and prognosis in cancer. Moreover, TOPK phosphorylates p38, JNK, ERK, and AKT, which are involved in many cellular functions, and participates in the activation of multiple signaling pathways related to MAPK, PI3K/PTEN/AKT, and NOTCH1.

Poids moléculaire: 37.61 kDa. Due to glycosylation, the protein migrates to 38-45 kDa based on Tris-Bis PAGE result.