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anti-Human MCM4 Anticorps:
anti-Rat (Rattus) MCM4 Anticorps:
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Human Polyclonal MCM4 Primary Antibody pour WB - ABIN967643
Coxon, Maundrell, Kearsey: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication. dans Nucleic acids research 1993
Show all 5 Pubmed References
Human Polyclonal MCM4 Primary Antibody pour IHC, PLA - ABIN151756
Song, Lafont, Chen, Wu, Shirahige, Rankin: Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery. dans The Journal of biological chemistry 2012
MCM4 and MCM7 (Montrer MCM7 Anticorps) expression is significantly correlated with Ki-67 (Montrer MKI67 Anticorps), Bmi1 (Montrer BMI1 Anticorps), and cyclin E (Montrer CCNE1 Anticorps) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.
We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin
Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase (Montrer DNAH8 Anticorps) activities to the complex containing wild-type MCM4
Mutant p53 (Montrer TP53 Anticorps) depletion profoundly influenced PARP1 (Montrer PARP1 Anticorps) localization and increased the level of PCNA (Montrer PCNA Anticorps) and MCM4 proteins.
Of the total, the deregulation of several genes (CDK1 (Montrer CDK1 Anticorps), CDK2 (Montrer CDK2 Anticorps), CDK4 (Montrer CDK4 Anticorps), MCM2 (Montrer MCM2 Anticorps), MCM3 (Montrer MCM3 Anticorps), MCM4, EIF3a (Montrer EIF6 Anticorps) and RPN2 (Montrer PSMD1 Anticorps)) were potentially associated with disease development and progression.
Mcm2-7 (Montrer MCM2 Anticorps) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
Peroxisome proliferator-activated receptor gamma (Montrer PPARG Anticorps) coactivator 1beta (PGC-1beta (Montrer PPARGC1B Anticorps)) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells
point mutation of MCM4 perturbs proper interaction with MCM6 (Montrer MCM6 Anticorps) to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 (Montrer MCM2 Anticorps) complex
Mutations in MCM4/PRKDC (Montrer PRKDC Anticorps) represent a novel cause of DNA breakage and NK cell deficiency.
Together, these data support a model in which chromosomal abnormalities in Sdl mice result from the ability of MCM4(D573H) to incorporate into MCM complexes and render them inactive.
partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency
MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency
role of subunits in DNA helicase acdtivity
Substrate preference and helicase (Montrer DNA2 Anticorps) actions of mouse MCM4/6/7 helicase (Montrer DNA2 Anticorps) complexes.
MCM4 phosphorylation by Cdc7 (Montrer CDC7 Anticorps) kinase facilitates its interaction with Cdc45 (Montrer CDC45 Anticorps) on chromatin
Hypomorphic alleles of Mcm4 may increase breast cancer risk.
Loss of one allele of cdc2l (Montrer CDK13 Anticorps) genefacilitates carcinogen-induced skin carcinogenesis in vivo.
Mcm4(Chaos3) mutation appears to destabilize the MCM2-7 (Montrer MCM2 Anticorps) complex, causing impaired DNA replication and may have a causative role in cancer development.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
DNA replication licensing factor mcm4
, MCM4 minichromosome maintenance deficient 4
, minichromosome maintenance protein 4
, DNA replication licensing factor MCM4
, CDC21 homolog
, homolog of S. pombe cell devision cycle 21
, minichromosome maintenance deficient 4
, mini chromosome maintenance deficient 4 homolog
, minichromosome maintenance deficient 4 homolog