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Human Radixin Protein expressed in HEK-293 Cells - ABIN2730421
Miyaji, Shahrizaila, Umapathi, Chan, Hirata, Yuki: Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies? dans Human immunology 2015
CPI-17 (Montrer PPP1R14A Protéines) drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin (Montrer NF2 Protéines) and activation of the growth promoting ERM (Montrer ETV5 Protéines) family.
Radixin knockdown suppresses the metastasis of SGC (Montrer SGCB Protéines)-7901 cells in vitro by up-regulation of E-cadherin (Montrer CDH1 Protéines). The NF-kappaB (Montrer NFKB1 Protéines)/snail (Montrer SNAI1 Protéines) pathway contributes to the regulation of E-cadherin (Montrer CDH1 Protéines) in response to depletion of radixin.
Phospho-Ezrin/Radixin/Moesin (ERM (Montrer MSN Protéines)) inhibit cell adhesion, and therefore, dephosphorylation of ERM (Montrer ETV5 Protéines) proteins is essential for cell adhesion.Phospho-ERM (Montrer ETV5 Protéines) induce formation and/or maintenance of spherical cell shape.
These studies identify Akt2 (Montrer AKT2 Protéines) as a critical kinase that regulates radixin phosphorylation and leads to Mrp-2 (Montrer ABCC2 Protéines) translocation and function.
Intracellular sphingosine kinase 2 (Montrer SPHK2 Protéines)-derived sphingosine-1-phosphate mediates epidermal growth factor (Montrer EGF Protéines)-induced ezrin-radixin-moesin (Montrer MSN Protéines) phosphorylation and cancer cell invasion.
High Radixin expression is associated with glioblastoma.
Ezrin (Montrer EZR Protéines), radixin and moesin (Montrer MSN Protéines) are unlikely targets for autoantibodies in demyelinating neuropathies.
Data show that silencing ezrin-radixin-moesin (ERM (Montrer MSN Protéines)) protein expression ablates deleted in colorectal carcinoma (Montrer DCC Protéines) protein (DCC (Montrer DCC Protéines))-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation.
These data suggest an association between RDX polymorphisms and the clinical features of RA patients, particularly the ESR (Montrer ESR1 Protéines)
Radixin was identified as a target gene of miR (Montrer MLXIP Protéines)-196a/-196b. Elevated miR (Montrer MLXIP Protéines)-196a/-196b expression in GC cells led to reduced radixin protein levels and vice versa.
LRBA (Montrer LRBA Protéines) deficiency is associated with a reduced abundance of radixin and Nherf2 (Montrer SLC9A3R2 Protéines), two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia.
Inactivation of SHIP2 (Montrer INPPL1 Protéines) leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin (Montrer MSN Protéines) proteins and increased Rho-GTP (Montrer AK3 Protéines).
identification of radixin as a PRG-2 (Montrer PTGR2 Protéines) interaction partner and showing that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2 (Montrer PTGR2 Protéines)
These results indicate that radixin plays an important role in regulating P-glycoprotein localization and P-glycoprotein functional activity at the intestinal membrane.
The specific location of radixin-positive cells in the peri (Montrer POSTN Protéines)-infarct region and in microglia suggests a role for radixin in microglial activation after stroke.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
the extracellular matrix molecule VN and its neuronal receptor TLCN (Montrer ICAM5 Protéines) play a pivotal role in the phosphorylation of ezrin/radixin/moesin (Montrer MSN Protéines) proteins and the formation of phagocytic cup-like structures on neuronal dendrites
Ezrin/radixin/moesin (Montrer MSN Protéines) are required for the purinergic P2X7 receptor (P2X7R (Montrer P2RX7 Protéines))-dependent processing of the amyloid precursor protein (Montrer APP Protéines).
The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers.
Ezrin-radixin-moesin (ERM (Montrer MSN Protéines)) proteins are induced in activated microglia/macrophages, whereas ERM (Montrer ETV5 Protéines) molecules are only marginally expressed in quiescent microglia in the normal brain.
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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