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The results demonstrated that high serum NGF concentrations were independently associated with the better functional prognosis at 3months following the occurrence of stroke.
p.R121W NGF mutation causes HSAN5 through negating the ability of furin to cleave proNGF to produce NGF-beta
These results suggest novel genetic susceptibility to primary localized provoked vulvodynia associated with specific alleles in genes TRPV1 and NGF and propose the rs222747 "C" allele of TRPV1 as a common genetic predisposition for other pain syndromes.
NGF (and BDNF) levels in peripheral blood mononuclear cells were reduced in Neuropsychiatric Systemic Lupus Erythematosus patients compared to healthy controls.
NGF expression in the livers with hepatolithiasis.NGF up-regulated SIRT1 expression in the hepatocytes.
the effects of secretome-enriched conditioned medium (CM) of neuronally differentiated PC12 cells on the neuronal differentiation of human mesenchymal stem cells via NGF like mechanism, is reported.
Single nucleotide polymorphisms in NGF gene (rs6330) and NGFR gene (rs2072446 and rs734194) are associated with ischemic stroke. The NGF rs6330*T and NGFR rs2072446*T minor alleles might be nominated as a risk factor for developing ischemic stroke and NGFR rs734194*G minor allele as a protective against this disease at least in Armenian population
Neurotrophic factors and hippocampal activity in PTSD
SNRPA may contribute to GC progression via NGF and could be a prognostic biomarker for GC.
Results show that NGF signalling is strongly linked to pathological and regenerative processes in human teeth.
The results suggest an interaction between NGF, GDNF and MMP-9 during the transition to malignancy in prostate cancer (PC). Also this interaction may involve in regulating PC cell differentiation, tumor invasion, progression, and the agressiveness of PC.
the anti-tumor activity of oleuropein against hepatocellular carcinoma could be attributed to influencing the pro-NGF/NGF balance via affecting MMP-7 activity without affecting the gene expression of NGF
co-expression patterns of NGF and heme oxygenase-1 might be used as prognostic indicators for gastric carcinoma patients
This review will briefly address the peripheral and central sensitization mechanisms of airway neurons and will then focus on NGF signaling and its role in cough hypersensitivity.[review]
First-trimester plasma nerve growth factor is lower in patients who subsequently develop preeclampsia.
This study show evidence of variation in plasmatic beta-NGF expression during the progression of dementia.
NGF is functionally linked to beta-catenin, promoting the migration of human ovarian cancer cells via the WNT/beta-catenin pathway.
Varicella zoster virus DNA replication is regulated in part by an NGF pathway that is PI3-kinase-independent.
Many studies indicate that the only presence of NGF is unable to generate cell carcinogenesis, both in normal neuronal and non-neuronal cells/tissues. However, it cannot be excluded the possibility that the co-expression of NGF and pro-carcinogenic molecules might open to different consequence. [review]
the effect and underlying mechanisms of NGF/BDNF on the production of NPW in PC12 cells and hypothalamus, is reported.
intra-adipose sympathetic plasticity regulated by NGF-TrkA signal in cold-induced beiging
Data indicate that nerve growth factor (NGF) impacts pancreatic ductal adenocarcinoma (PDAC) progression and metastasis in a temporally dependent manner.
structural analysis of binding of NGF, proNGF, and proBDNF to SorCS2
The authors described a long-distance signaling mechanism of Porcine hemagglutinating encephalomyelitis virus-driven deficits in neurons and suggested that such Ulk1 repression may result in limited NGF/TrkA retrograde signaling within activated Rab5 endosomes, explaining the progressive failure of neurite outgrowth and survival.
Mechanoinsensitive ''silent'' nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3); the mechanically gated ion channel PIEZO2 mediates NGF-induced mechanosensitivity in these neurons.
antibodies raised against NGF, TrkA, and p75 (also known as CD271) were used to explore the expression of these antigens in the non-decalcified young mouse femur.
An inducible mouse model that can dissect the contribution of autocrine direct action of cleavage-resistant proNGF on systemic microvascular abnormalities in both retina and kidney, major targets for microvascular complication.
both in vivo mechanical loading and in vitro mechanical stretch were shown to induce the profound up-regulation of NGF in osteoblasts within 1 h of loading.
Nerve growth factor negatively regulates bone marrow granulopoiesis during small intestinal inflammation
This study may represent a common mechanism for selective follicular activation induced by a localized increase in NGF in interstitial cells and mediated via the mTOR signaling pathway.
nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression.
These data support a role for islet NGF in fine-tuning insulin secretion.
Mechanical stress-induced upregulation of NGF in colon SMC underlies the visceral hypersensitivity in bowel obstruction through increased gene expression and activity of tetrodotoxin-resistant Na channels in sensory neurons.
results suggest that perivascular nerves innervate neovessels as neovasculatures mature and that NGF accelerates the innervation of perivascular nerves in neovessels.
These findings reveal a non-neuronal role for neurotrophins and identify a new regulatory pathway in insulin secretion that can be targeted to ameliorate beta cell dysfunction.
NGF signalling directly controls basal APP phosphorylation, subcellular localization and BACE cleavage.
NGF facilitates OVA with lowLPS-induced maturation of mouse BMDCs through LPS-up-regulated p75 NTR via activation of NF-kappaB pathways, providing another mechanism for the involvement of NGF in the Th2 response
NGF-OE mice exhibit age-dependent increases in Substance P and CGRP in the urothelium and hyperinnervation of the bladder.
TNF-alpha upregulated Nerve Growth Factor [NGF] expression in synovial fibroblasts and macrophages and IL-1beta upregulated NGF expression in synovial fibroblasts. IL-1beta and TNF-alpha may regulate NGF signaling in Osteoarthritic joints and be suitable therapeutic targets for treating Osteoarthritis pain
functional PAP(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA signaling.
The present study indicates that caveolin-containing rafts/caveolins such as caveolin-1 could play a modulating role during oligodendroglial differentiation and regeneration via NGF/TrkA signaling.
we demonstrate the sensitizing effect of NGF on pig skin nociceptors; long-lasting sensitization processes of nociceptor endings or axonal sodium channel desensitization mechanisms can be explored in the pig as a translational experimental animal model
NGF, TrkA and p75 are expressed in the ovary during the estrous cycle in gilts
There is up-regulation of NGF mRNA and protein expression in the porcine uterus when affected by E. coli-induced in-flammation.
This study demonstrated for the first time a strong expression of NGF, TrkA, CGRP, nNOS and neuronal specific enolase in the majority of esophageal enteric nervous system components.
report describing differential expression of proteins and mRNA for NGF and its cognate receptors, NTRK1 and NGFR, in the male sex organs of rabbits
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
beta-nerve growth factor
, nerve growth factor, beta subunit
, nerve growth factor, beta
, nerve growth factor
, nerve growth factor beta subunit
, beta-beta-nerve growth factor
, nerve growth factor, beta polypeptide
, nerve growth factor (beta polypeptide) S homeolog
, nerve growth factor prepropeptide
, nerve growth factor (beta polypeptide)
, nerve growth factor B