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Human FCGR1 Protein expressed in Human Cells - ABIN2002442
Barnes, Gavin, Tan, Mottram, Koentgen, Hogarth: FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. dans Immunity 2002
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Opsonization by Friend virus-specific non-neutralizing IgG abrogated DC infection and as a consequence significantly reduced the capacity of Dendritic cells (DCs) to activate virus-specific CD8 T cells. Effects of IgG-opsonization were mediated by the high-affinity FcgammaR type I, CD64, expressed on DCs.
FcgammaRI plays a role on macrophages to involve in renal inflammatory response, potentially via regulating the NLRP3 inflammasome-associated signaling.
investigated consequences of 3 nonsynonymous SNPs for FcgammaRI; only SNP V39I reduces immune-complex binding of FcgammaRI whereas monomeric IgG binding is unaffected; SNPs I301M and I338T have no influence on monomeric IgG or immune complex binding, but FcRgamma signaling is decreased for both SNPs
FcgammaRI/FcgammaRIIB expression ratio in splenic macrophages was higher in the Treg-deficient immune thrombocytopenia (ITP) than in the Treg-deficient non-ITP and control mice
The IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRI.
Dbn1 regulates systemic anaphylaxis and IgE/Fcgr1-induced degranulation in mast cells by regulating actin reorganization and actin dynamics.
This study demonstrated that the activating FcgammaRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS.
N-glycans in FcgammaRIa interact with the OmpA of E. coli K1 for inducing disease pathogenesis
observations suggest that IgG-mediated inhibition of fibrocyte differentiation is mediated by FcgammaRs, with FcgammaRI mediating most of the signaling.
Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.
The PI3K inhibitor LY294002 inhibited BCR-mediated, but not TLR-mediated, induction of IkappaB-zeta, consistent with the role of PI3K in BCR signaling and its suppression by FcgammaR.
Dap12- and FcRgamma-deficiency exacerbates Granulocyte-Macrophage Colony-Stimulating Factor-driven monocyte differentiation and production of inflammatory monocyte-derived dendritic cells.
Tpl2 is activated by FcgammaR signals in macrophages and that its activation by these signals is required for ERK activation, cytoplasmic Ca(2+) influx, the induction of cytokine and coreceptor gene expression, and phagocytosis.
FcgammaRI partially mediates the protective effect of monoclonal antibody TA99 on metastatic melanoma tumor loads.
The mechanism(s) of phagocytosis in the second phase of blood incompatibility reaction required neither C3 nor FcgammaRs.
observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation
CRP antagonism of eNOS is mediated by coupling of FcgammaRI to FcgammaRIIB by Src kinase and activation of inositol 5'-phosphatase 1, and consistent with this mechanism, both FcgammaRI and FcgammaRIIB are required for CRP to blunt endothelial repair in vivo.
IgG FcgammaRI (CD64) is a target of miR-127, as evidenced by reduced CD64 protein expression in macrophages overexpressing miR-127.
This review notes that the role of murine FcgammaRI differs considerably from human, based on sequence data, existence of the FcgammaRI variable region, and overview of disease models.
CD64 expression in macrophages is critical for the onset of meningitis by Escherichia coli K1.
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
IgG high affinity Fc receptor
, fc-gamma RI
, high affinity immunoglobulin gamma Fc receptor I
, igG Fc receptor I