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Because Trp72 is the highly conserved in the ligand binding sites of galectins, we used EGFP-tagged W72A to show that Gal-10 could not be transported into the nucleus, indicating that Trp72 is crucial for Gal-10 transport into that organelle.
findings show that galectin-10 functions as a T cell-suppressive molecule in eosinophils
The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation.
CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC.
DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents
Genetic variation in Charcot-Leyden crystal protein was found to be associated with allergic rhinitis
downregulated significantly in acute myeloid leukemia patients whose white blood cell count was higher than 100 x 10(9)/L cells
Changes in the expressions of galectin-10 are potentially important for myeloid cell differentiation into specific lineages.
The five genes, and three of the encoded proteins, were shown differentially expressed between a group of keratoconus patients and a reference group using different techniques
Downregulated in whole blood of infants hospitalised with respiratory syncytial virus (RSV), subtype B, bronchiolitis.
expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25(+) Treg cells.
Data show that galectin-10 expression was related to the histological grade and with the number of eosinophils in the lesion.
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.
Charcot-Leyden crystal protein
, eosinophil lysophospholipase
, galectin 10
, lectin, galactoside-binding, soluble, 10
, lysolecithin acylhydrolase
, Charcot-Leyden crystal protein homolog