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Human Corin Protein expressed in HEK-293 Cells - ABIN2712504
Yin, Li, Zhang, Yang, Sun, Cao, Xiang: Sensitive and low-background electrochemical assay of corin activity via supramolecular recognition and rolling circle amplification. dans Analytica chimica acta 2016
corin may play important roles in aorta physiology and in the pathophysiological process of atherosclerosis in an autocrine manner
plasma corin levels are inversely correlated with heart function and may reflect the severity of myocardial damage
Residues Lys-71, Phe-72 and Gln-73 serve as a novel retention motif in the intracellular pathway to regulate corin cell surface expression and activation.
N-glycans at different sites may play distinct roles in regulating the cell membrane targeting, zymogen activation, and ectodomain shedding of corin
These results provide the first experimental evidence that corin expression plays a role in cardiomyopathy by modulating myocardial fibrosis, cardiac function, heart failure, and survival.
Data show that KO/TgV mice had significantly higher levels of proatrial natriuretic peptide in the heart compared with that in control KO/TgWT mice, indicating that the corin variant was defective in processing natriuretic peptides in vivo.
Lack of corin in mice impairs their adaptive renal response to high dietary salt, suggesting that corin deficiency may represent an important mechanism underlying salt-sensitive hypertension.
results indicate that corin and ANP are essential for physiological changes at the maternal-fetal interface, suggesting that defects in corin and ANP function may contribute to pre-eclampsia
Data indicate that Corin's involvement in ANP processing is a key element in the heart's response to increased hemodynamic load
Ectodomain shedding and autocleavage of the cardiac membrane protease corin.
corin might be involved in the salt retention seen in glomerular diseases.
Insufficient corin activation is expected to prevent natriuretic peptide processing and may contribute to body fluid retention and impaired cardiac function in patients with heart failure.
Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes.
These data indicate that the GATA element and its binding to GATA-4 are essential for cardiac expression of the human and murine corin genes.
data establish corin as the physiological pro-ANP convertase and indicate that corin deficiency may contribute to hypertensive heart disease (pro-ANP convertase corin)
N-linked oligosaccharides play an important role in corin activation
Native corin is a glycosylated protease that is localized on the cell surface of pro-ANP-expressing cardiomyocytes in both zymogen and catalytically active forms.
Corin plays a critical role in specifying coat color and acts downstream of agouti gene expression as a suppressor of the agouti pathway.
N-glycosylation is essential for the cell-surface expression of murine corin and modulates its functional activity.
Data report that W(sh) animals exhibit splenomegaly with expanded myeloid and megakaryocyte populations, related to the disruption of corin through chromosome inversion.
Data suggest that soluble corin lacking transmembrane domain is activated by PCSK6 in conditioned medium or in cell-free system but not intracellularly; cell membrane association is unnecessary for PCSK6 to activate corin; soluble corin and PCSK6 are secreted by cardiomyocytes (or HEK293 cells) via different intracellular pathways. (PCSK6 = proprotein convertase subtilisin/kexin type-6)
Suggest that pro-ANP/corin/NPR-C signaling is dominant in the vascular system in preeclampsia.
These results indicate that genetic variants impairing corin function are not uncommon in general populations and that such variants may be an important contributing factor in hypertension.
Preeclampsia is one of the most severe complications of the pregnancy, and trials to estimate a panel of predictive markers are of big interest for multiple researches. Corin is a transmembrane serine protease, localized in the heart, which is converting pro-ANP in to active ANR. ANP is a hormone regulating salt hemostasis and arterial blood pressure. [review]
Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease.
association of 2 single nucleotide polymorphisms in CORIN (rs2271037 and rs3749585) with hypertension, as well as their potential interactions with some risk factors of hypertension in a Han population of northeastern China
We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension.
Corin and atrial natriuretic peptide A were most abundant in the proximal convoluted tubules and the medullary connecting ducts.
CORIN expression is significantly downregulated in human masticatory mucosa during wound healing
serum levels of corin are significantly decreased in acute myocardial infarction patients
Data show that both furin and brain type natriuretic peptide (BNP) were more sensitive than corin in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.
Circulating corin concentrations are related to infarct size in patients after ST-segment elevation myocardial infarction
Hypertensive participants had an increased serum corin level compared to those without hypertension, suggesting that corin may play a role in the pathology of hypertension.
Serum soluble corin was significantly and positively associated with dyslipidemia
Plasma corin levels decreased significantly from preoperative concentrations after coronary artery bypass graft surgery.
corin may play an important role in the pathology of atrial fibrillation
Increased serum soluble corin in mid pregnancy was associated with an increased risk for HDP(hypertensive disorders of pregnancy) .--increased serum soluble corin in mid pregnancy could be an indicator for HDP
identified a PCSK6 mutation that impaired corin activation activity in a hypertensive patient
the variant altered corin structure and impaired the natriuretic peptide processing activity in vivo. The results highlight corin defects as an important underlying mechanism in hypertension.
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
corin, serine peptidase
, novel protein similar to H.sapiens CORIN, corin, serine peptidase (CORIN)
, atrial natriuretic peptide-converting enzyme-like
, atrial natriuretic peptide-converting enzyme
, low density lipoprotein receptor-related protein 4
, low density lipoprotein-related protein 4
, pro-ANP-converting enzyme
, heart-specific serine proteinase ATC2
, transmembrane protease serine 10