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Sipa1 loss-induced BM niche alterations likely enable evolution of clonal hematopoiesis to the hematological malignancies.
Sipa1 deficiency uncovers a host immune mechanism potentially capable of eradicating Bcr-Abl(+) hematopoietic progenitor cells.
Sipa1 polymorphism is one of the genetic polymorphisms underlying the metastasis efficiency locus Mtes1.
The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.
afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1.
SIPA1 promotes oral squamous cell carcinoma metastasis by regulating the ITGB1 and MMP7.
Study shows that SIPA1 mRNA and protein expression are down-regulated in gastric cancer cells and correlate with tumor grading, invasion and lymph node metastasis as well as higher expression of VEGFA. Low SIPA1 levels in gastric cancer may then accelerate tumor development and progression by promoting VEGFA expression to increase vascular density.
results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis
Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression.
nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling.
BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.
This meta-analysis suggests that rs746429 is associated with the risk of breast cancer.
SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors.
Polymorphism in Sipa1 promoter gene is associated with lung cancer.
Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042).
SIPA1 expression is increased in human colorectal cancer.
In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 after controlling for stage and lymphvascular space invasion.
role in regulating phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion
Data identif a Rap GTPase-activating protein, signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4.
SIPA1 germline polymorphisms are associated with aggressive disease behavior in breast cancer.
SPA1 regulates the maintenance and differentiation of embryonic stem cells.
it is unlikely that SIPA1 plays a pathogenetic role in the development of juvenile myelomonocytic leukemia
Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival
SIPA1 SNP rs3741378 was associated with increased breast cancer incidence.
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
signal-induced proliferation-associated gene 1
, Signal peptidase I (leader peptidase I)
, signal-induced proliferation-associated 1
, signal-induced proliferation-associated protein 1-like
, GTPase-activating protein Spa-1
, signal-induced proliferation-associated protein 1
, p130 SPA-1