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Human Polyclonal EIF6 Primary Antibody pour ELISA, WB - ABIN561554
Peng, Yuan, Tan, Ma, Bian, Xu, He, Cao, Huang, Cui, Gan, Wang, Zhou, Hu, Yang, Luo, Wu: Identification of ITGB4BP as a new interaction protein of P311. dans Life sciences 2012
Human Polyclonal EIF6 Primary Antibody pour ICC, IF - ABIN4327199
Li, Luco, Ochietti, Fadhil, Camirand, Reinhardt, St-Arnaud, Muller, Kremer: Tumoral Vitamin D Synthesis by CYP27B1 1-α-Hydroxylase Delays Mammary Tumor Progression in the PyMT-MMTV Mouse Model and Its Action Involves NF-κB Modulation. dans Endocrinology 2016
Studies indicate that eukaryotic translation initiation factor 6 (eIF6) is a central regulator of metabolism independent from mTOR (Montrer FRAP1 Anticorps) protein and myc proto-oncogene protein (Myc (Montrer MYC Anticorps)).
Propose that eIF6 is necessary for malignant pleural mesothelioma growth.
EIF6 plays an important role in controlling cell motility and tumor metastasis.
eIF6 is a node regulator of ribosomal function and predict that prioritizing its pharmacological targeting will be of benefit in cancer and Shwachman-Bodian-Diamond syndrome
SBDS (Montrer SBDS Anticorps) protein facilitates the release of eIF6, a factor that prevents ribosome joining.
eIF6 is one of the downstream effectors of Notch-1 (Montrer NOTCH1 Anticorps) in the pathway that controls cell motility and invasiveness in tumor cell lines
The interactions between P311 (Montrer C5orf13 Anticorps) and ITGB4BP may be very important in the process of tumor cell differentiation and metastasis.
The benign prognosis of the Shwachman-Diamond syndrome patients with the int del (20)(q11.21q13.32) may be due to a gene/dosage effect for the EIF6 protein.
Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6) and hnRNA splicing (SF3B2 (Montrer SF3B2 Anticorps)/SF3B4 (Montrer SF3B4 Anticorps)), showed that human T cells can enter the cell cycle without growing in size.
a direct role for SBDS (Montrer SBDS Anticorps) and EFL1 (Montrer EFNA1 Anticorps) in catalyzing the translational activation of ribosomes in all eukaryotes, and define SDS (Montrer SDS Anticorps) as a ribosomopathy caused by uncoupling GTP (Montrer AK3 Anticorps) hydrolysis from eIF6 release
Taken together, these results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-beta1 (Montrer TGFB1 Anticorps)/TGFBR1 (Montrer TGFBR1 Anticorps)/TGFBR2 (Montrer TGFBR2 Anticorps) pathway.
eIF6 relieved fibrosis/cicatrization by inhibiting the generation of VEGF (Montrer VEGFA Anticorps) to prevent the overgrowth of blood vessels and production of granulation tissues, and by regulating the MMP-2 (Montrer MMP2 Anticorps)/TIMP-2 (Montrer TIMP2 Anticorps) balance to promote ECM (Montrer MMRN1 Anticorps) degradation and decrease its deposition.
data reveal a novel transcriptional regulatory mechanism of eIF6 that acts on facilitating Sp1 (Montrer SP1 Anticorps) recruitment to TGF-beta1 (Montrer TGFB1 Anticorps) promoter via H2A.Z (Montrer H2AFZ Anticorps) depletion and thus results in increased TGF-beta1 (Montrer TGFB1 Anticorps) transcription, which contributes to myofibroblast differentiation.
Reduced eIF6 expression negatively impacts on megakaryopoiesis. in eIF6(+/-) cells, the steady-state abundance of mitochondrial respiratory chain complex I-encoding mRNAs is decreased, resulting in decreased reactive oxygen species production.
eIF6 controls fatty acid synthesis and glycolysis in a cell autonomous fashion. Translational activation by eIF6 reshapes gene expression with increased levels of lipogenic and glycolytic enzymes.
In a murine model of lymphomagenesis, eIF6 depletion leads to a striking increase of survival, without adverse effects.
eIF6 is a rate-limiting controller of initiation of translation, able to affect tumorigenesis and tumor growth.
eIF6 is the first eIF associated with the large 60S subunit that regulates translation in response to extracellular signals
Results suggest that eif6 regulation of Kermit 2/XGIPC (gipc2) enables correct morphogenesis of eye.
aberrant eye phenotype, produced by eif6 overexpression, is not directly linked to the PKC (Montrer PKC Anticorps)-regulated effects of eif6 on translation and ribosomal subunit interaction
The higher presence of p27BBP/eIF6 would appear related to an increased need of apoptosis control in the regions where cell death is essential for normal development.
Xp27(BBP (Montrer TM2D1 Anticorps))/eIF6 is part of a mechanism acting on the specific translation of messengers regulating cell survival; Xp27(BBP (Montrer TM2D1 Anticorps))/eIF6 may regulate the translation of factors upstream of Bcl-2 (Montrer BCL2 Anticorps)/Bax (Montrer BAX Anticorps).
The distribution of p27BBP/eIF6 and its association with the cytoskeleton varies according to oogenesis stages.
p27BBP/eIF6 expression is modulated during embryogenesis in differentiating anlagens and may suggest a correlation between p27BBP/eIF6 and proliferative activity.
results uncover an evolutionarily conserved function of the ribosome anti-association factor eIF6 in miRNA-mediated post-transcriptional silencing
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.
B4 integrin interactor
, eukaryotic translation initiation factor 3A
, p27 beta-4 integrin-binding protein
, imc-415 homolog
, integrin beta 4 binding protein
, eukaryotic translation initiation factor 6