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once inside the nucleus, P2X6 (Montrer P2RX6 Protéines) subunit interacts with the splicing factor 3A1, which ultimately results in a reduction of the mRNA splicing activity
Polymorphisms in SF3A1 gene is associated with pancreatic cancer.
SF3A1 polymorphisms are not associated with Colorectal Cancer Risk.
show that U1-SL4 interacts with the SF3A1 protein of the U2 snRNP (Montrer LSM2 Protéines)
SF3a60 (Montrer SF3A3 Protéines), 66, and 120, but not SF1 (Montrer NR5A1 Protéines), are essential for pre-mRNA splicing
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family\; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
, splicing factor 3a, subunit 1
, splicing factor 3A subunit 1
, ubiquitin domain-containing protein
, Splicing factor 3 subunit 1
, splicing factor 3 subunit 1
, splicing factor 3a, subunit 1, 120kDa
, SAP 114
, pre-mRNA processing 21
, pre-mRNA splicing factor SF3a (120 kDa subunit)
, spliceosome-associated protein 114