Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
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Dernières publications sur nos produits RPSA/Laminin Receptor
Umbaugh, Diaz-Quiñones, Neto, Shearer, Figueiredo: "A dock derived compound against laminin receptor (37 LR) exhibits anti-cancer properties in a prostate cancer cell line model." dans: Oncotarget, Vol. 9, Issue 5, pp. 5958-5978, (2018) (PubMed).
Wang, Yu, Guan, Liu, Qiao: "67-kDa Laminin receptor contributes to hypoxia-induced migration and invasion of trophoblast-like cells by mediating matrix metalloproteinase-9." dans: Clinical and experimental pharmacology & physiology, Vol. 42, Issue 5, pp. 549-58, (2015) (PubMed).
Santamarina, Oliveira, Silva, Carnier, Mennitti, Santana, de Souza, Ribeiro, Oller do Nascimento, Lira, Oyama: "Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0141227, (2015) (PubMed).
Song, Choi, Cho, Sung, Song, Kim, Bae, Lee, Kim: "Expression of 67-kDa laminin receptor was associated with tumor progression and poor prognosis in epithelial ovarian cancer." dans: Gynecologic oncology, Vol. 125, Issue 2, pp. 427-32, (2012) (PubMed).
Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
Starborg, Gell, Brundell, Höög: "The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression." dans: Journal of cell science, Vol. 109 ( Pt 1), Issue 12, pp. 143-53, (1996) (PubMed).
Synonymes et noms alternatifs relatifs à RPSA/Laminin Receptor
40S ribosomal protein SA (rssa), 67kD laminin receptor (rpsa), ribosomal protein SA (RPSA), ribosomal protein SA (Rpsa), ribosomal protein SA (rpsa), 40S ribosomal protein SA (LOC100144340), 37LRP, 67kDa, 67LR, 67lr, AL022858, DMRT1, LAMBR, LamR, lamR, Lamr, LamR1, LAMR1, Lamr1, lamr1, Lamrl1, LBP, LBP/p40, LRP, LRP/LR, MLR, NEM/1CHD4, p40, P40, P40-3, P40-8, rpsa, RPSA, SA, zgc:55831, zgc:77824
Protein level used designations for RPSA/Laminin Receptor