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Human RAF1 Protein expressed in Wheat germ - ABIN1317314
Rodríguez-Muñoz, de la Torre-Madrid, Sánchez-Blázquez, Garzón: NO-released zinc supports the simultaneous binding of Raf-1 and PKC? cysteine-rich domains to HINT1 protein at the mu-opioid receptor. dans Antioxidants & redox signaling 2011
Data indicate that Raf-1 proto-oncogene (Montrer RAB1A Protéines), serine-threonine kinase (Montrer TLK2 Protéines) (RAF1) is a negative regulator of hepatocarcinogenesis.
we report a patient with an inherited RAF1-associated Noonan syndrome, presenting with an antenatally diagnosed abnormality of skull shape, bilateral subdural haematomas, of unknown cause, delayed myelination and polymicrogyria.
Raf1 may serve as a novel prognostic factor and potential target for improving the longterm outcome of nonsmall cell lung cancer (NSCLC).
Results provide evidence that RAF1 binding to SPRY4 (Montrer SPRY4 Protéines) is regulated by miR (Montrer MLXIP Protéines)-1908 in glioma tumors.
High RAF1 expression is associated with malignant melanoma.
two premature neonates with progressive biventricular hypertrophy found to have RAF1 variants in the CR2 domain, are reported.
Data indicate connector enhancer of kinase suppressor of Ras 1 (Montrer CNKSR1 Protéines) protein (CNK1 (Montrer CNKSR1 Protéines)) as a molecular platform that controls c-raf protein (RAF) and c-akt (Montrer AKT1 Protéines) protein (AKT (Montrer AKT1 Protéines)) signalling and determines cell fate decisions in a cell type- and cell stage-dependent manner.
CRAF is a bona fide alternative oncogene (Montrer RAB1A Protéines) for BRAF (Montrer BRAF Protéines)/NRAS (Montrer NRAS Protéines)/GNAQ (Montrer GNAQ Protéines)/GNA11 (Montrer GNA11 Protéines) wild type melanomas
Authors evaluated the expression of known targets of miR (Montrer MLXIP Protéines)-125a and found that sirtuin-7 (Montrer SIRT7 Protéines), matrix metalloproteinase-11 (Montrer MMP11 Protéines), and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR (Montrer MLXIP Protéines)-125a.
Overexpression of ciRS-7 in HCT116 and HT29 cells led to the blocking of miR-7 (Montrer LILRB1 Protéines) and resulted in a more aggressive oncogenic phenotype, and ciRS-7 overexpression permitted the inhibition of miR-7 (Montrer LILRB1 Protéines) and subsequent activation of EGFR (Montrer EGFR Protéines) and RAF1 oncogenes
cdk10 (Montrer CDK10 Protéines) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
data suggest that G alpha(i3), Shc (Montrer SHC1 Protéines), Grb2 (Montrer GRB2 Protéines), Ras, and Raf-1 link Src (Montrer SRC Protéines) to activation of MAPK (Montrer MAPK1 Protéines) and to the AT(2)-dependent increase in eNOS (Montrer NOS3 Protéines) expression in PAECs
Data indicate that Raf-1 proto-oncogene (Montrer RAB1A Protéines), serine-threonine kinase (Montrer CDK4 Protéines) (RAF1) is a negative regulator of hepatocarcinogenesis.
Results indicate that proto-oncogene c-RAF (CRAF) function affects postmitotic neural cell differentiation and points to a critical role of CRAF-dependent growth factor signaling pathway in the postmitotic development of adult-born neurons.
our studies demonstrate that PDE8A (Montrer PDE8A Protéines) inhibition by enzymatic inhibitors or PDE8A (Montrer PDE8A Protéines)-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation
BRAF (Montrer BRAF Protéines) and ROKalpha (Montrer ROCK2 Protéines) form independent RAF1 complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (Montrer EGF Protéines)).
Mechanistically, BRAF (Montrer BRAF Protéines) and RAF1 operate independently to balance MAPK (Montrer MAPK1 Protéines) signaling: BRAF (Montrer BRAF Protéines) promotes ERK (Montrer EPHB2 Protéines) activation, while RAF1 dims stress kinase activation.
Neuroprotective (arylthio)cyclopentenone prostaglandins directly bind to c-Raf protein and protect cells from down-regulation of the c-Raf protein itself, resulting in protection against oxidative stress.
Additional Cyp (Montrer PPIG Protéines) genes are disregulated in the absence of Zhx2 (Montrer ZHX2 Protéines).
Zhx2 (Montrer ZHX2 Protéines) is a novel regulator of Mup expression; Zhx2 (Montrer ZHX2 Protéines) activates as well as represses expression of target genes
A- and B-Raf (Montrer SNRPE Protéines) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (Montrer VEGFA Protéines) protein stability.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 (Montrer RPS6KA2 Protéines) was increased in Raf1(L613V) mice. Constitutive RSK3 (Montrer RPS6KA2 Protéines) gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
Both c-Raf and B-Raf (Montrer BRAF Protéines) are required for Ras-induced MEK1 (Montrer MAP2K1 Protéines) and p42 (Montrer EPB42 Protéines) MAP kinase (Montrer MAPK1 Protéines) activation.
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
, RAF proto-oncogene serine/threonine-protein kinase
, proto-oncogene c-RAF
, raf proto-oncogene serine/threonine protein kinase
, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
, v-raf-1 murine leukemia viral oncogene homolog 1
, murine leukemia viral oncogene homolog
, serine/threonine protein kinase RAF1
, MIL proto-oncogene serine/threonine-protein kinase
, c-mil protein
, murine leukemia viral (v-raf-1) oncogene homolog 1
, RAF proto-oncogene serine/threonine-protein kinase-like
, AFP regulator 1
, alpha fetoprotein regulation 1, adult
, alpha-fetoprotein regulator 1
, regulator of AFP
, zinc finger and homeodomain protein 2
, zinc fingers and homeoboxes protein 2
, Craf1 transforming
, murine sarcoma 3611 oncogene 1
, sarcoma 3611 oncogene
, v-raf-1 leukemia viral oncogene 1
, Proto-oncogene c-RAF