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anti-Human Insulin Receptor Anticorps:
anti-Mouse (Murine) Insulin Receptor Anticorps:
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Human Polyclonal Insulin Receptor Primary Antibody pour IF, WB - ABIN968448
Kasus-Jacobi, Béréziat, Perdereau, Girard, Burnol: Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. dans Oncogene 2000
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Rat (Rattus) Polyclonal Insulin Receptor Primary Antibody pour IF, WB - ABIN968449
Lu, Guidotti: Identification of the cysteine residues involved in the class I disulfide bonds of the human insulin receptor: properties of insulin receptor monomers. dans Molecular biology of the cell 1997
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Mouse (Murine) Monoclonal Insulin Receptor Primary Antibody pour IF, IP - ABIN967752
Ebina, Ellis, Jarnagin, Edery, Graf, Clauser, Ou, Masiarz, Kan, Goldfine: The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. dans Cell 1985
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Mouse (Murine) Monoclonal Insulin Receptor Primary Antibody pour IF, IP - ABIN967753
Frattali, Treadway, Pessin: Insulin/IGF-1 hybrid receptors: implications for the dominant-negative phenotype in syndromes of insulin resistance. dans Journal of cellular biochemistry 1992
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Human Monoclonal Insulin Receptor Primary Antibody pour FACS - ABIN2689096
Soos, OBrien, Brindle, Stigter, Okamoto, Whittaker, Siddle: Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts. dans Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal Insulin Receptor Primary Antibody pour IHC (p) - ABIN2479300
Jamner, Shapiro, Goldstein, Hug: Ambulatory blood pressure and heart rate in paramedics: effects of cynical hostility and defensiveness. dans Psychosomatic medicine 1991
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Human Polyclonal Insulin Receptor Primary Antibody pour CyTOF, FACS - ABIN4900627
Purushothaman, Babitz, Sanderson: Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. dans The Journal of biological chemistry 2012
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Human Polyclonal Insulin Receptor Primary Antibody pour IF (p), IHC (p) - ABIN671841
Bai, Chen, Liu, Tian, Zhou, Liu, Fang, Chen: Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice. dans Journal of ethnopharmacology 2009
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Human Polyclonal Insulin Receptor Primary Antibody pour WB - ABIN4226906
Cappuzzo, Toschi, Tallini, Ceresoli, Domenichini, Bartolini, Finocchiaro, Magrini, Metro, Cancellieri, Trisolini, Crino, Bunn, Santoro, Franklin, Varella-Garcia, Hirsch: Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib. dans Annals of oncology : official journal of the European Society for Medical Oncology 2006
Human Polyclonal Insulin Receptor Primary Antibody pour FACS - ABIN4897184
Mancini, Gariboldi, Taiana, Bonzi, Craparotta, Pagin, Monti: Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. dans British journal of cancer 2014
The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.
INSR rs2252673 and rs3745546 polymorphisms were associated with sensitivity to platinum-based chemotherapy in epithelial ovarian cancer patients and rs2252673 polymorphism may be an independent risk factor for EOC prognosis.
The IGF1R (Montrer IGF1R Anticorps) purified in n-dodecyl-beta-D-maltoside showed ligand-stimulated autophosphorylation and kinase activity, suggesting an intact transmembrane signaling mechanism.
Signaling via the insulin (INS (Montrer INS Anticorps)) and insulin-like growth factor 1 (IGF1 (Montrer IGF1 Anticorps)) receptors (INSR and IGF1R (Montrer IGF1R Anticorps)) regulate basal cell (BC) differentiation into ciliated cells.
High INSR expression is associated with drug Resistance in Gastrointestinal Stromal Tumors.
the above data indicate a direct role for IR expression as a determinant of PT-gluconeogenesis. Thus reduced insulin (Montrer INS Anticorps) signaling of the proximal tubule may contribute to hyperglycemia in the metabolic syndrome via elevated gluconeogenesis.
Activation of D4 receptor inhibits insulin receptor expression in RPT cells from WKY rats. The aberrant inhibition of D4 receptor on insulin receptor expression and effect might be involved in the pathogenesis of essential hypertension.
The HIR (Montrer KCNJ4 Anticorps) MAb binds the insulin receptor on the BBB (Montrer ALMS1 Anticorps).
data indicate that post-receptor signalling abnormalities might contribute to Myotonic dystrophy insulin (Montrer INS Anticorps) resistance regardless the alteration of INSR splicing.
We identified vascular INSR expression as a potential biomarker for progression in bladder cancer. The data suggest that IGF-2/INSR mediated paracrine crosstalk between bladder cancer cells and endothelial cells is functionally involved in tumour angiogenesis and may thus represent a new therapeutic target.
long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.
the overlap of IR and IGF1R (Montrer IGF1R Anticorps) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (Montrer FOXO3 Anticorps)-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (Montrer PRKCE Anticorps) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (Montrer INS Anticorps) resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP (Montrer AGRP Anticorps) neurons (AgRP (Montrer AGRP Anticorps) IR KO) exhibited impaired hepatic insulin (Montrer INS Anticorps) action because the ability of insulin (Montrer INS Anticorps) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (Montrer INS Anticorps) to suppress lipolysis was unaltered. To the contrary, in POMC (Montrer POMC Anticorps) IR KO mice, insulin (Montrer INS Anticorps) lowered hGP but failed to suppress adipose tissue lipolysis.
Intracellular retention of the insulin receptor is caused by elevated amounts of alpha-taxilin (Montrer TXLNA Anticorps), a free syntaxin binding protein, in HBV expressing hepatocytes preventing proper targeting of the insulin receptor to the cell surface.
Results found that glioblastoma tumors resistant to PDGFR (Montrer PDGFRB Anticorps) inhibition required the expression and activation of the insulin receptor (IR)/insulin (Montrer INS Anticorps) growth-like factor receptor (IGF1R (Montrer IGF1R Anticorps)) for tumor cell proliferation and survival.
The IR in the intestinal epithelium plays important roles in intestinal gene expression, glucose uptake, and GIP (Montrer GIP Anticorps) production, which may contribute to pathophysiological changes in individuals with diabetes, metabolic syndrome, and other insulin (Montrer INS Anticorps)-resistant states.
In conclusion, we have identified that ARL15 acts as an insulin (Montrer INS Anticorps)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (Montrer IRS1 Anticorps)/PDPK1 (Montrer PDPK1 Anticorps)/AKT (Montrer AKT1 Anticorps) insulin (Montrer INS Anticorps) pathway by interacting with its GAP ASAP2 (Montrer ASAP2 Anticorps) and activating PDPK1 (Montrer PDPK1 Anticorps). This research may provide new insights into GTPase (Montrer RACGAP1 Anticorps)-mediated insulin (Montrer INS Anticorps) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (Montrer INS Anticorps) sensitizati
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL (Montrer CTSA Anticorps) biosynthesis, prevents inappropriate activation of insulin (Montrer INS Anticorps) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (Montrer IGF1 Anticorps), IGF-2, IGFBP-2 (Montrer IGFBP2 Anticorps), IGFBP-3 (Montrer IGFBP3 Anticorps), IGF-1R (Montrer IGF1R Anticorps), IGF-2R, GHR (Montrer GHR Anticorps), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH (Montrer BRD2 Anticorps), but not E2, stimulated the expression of IR and GHR (Montrer GHR Anticorps) genes during follicular development.
Data conclude that insulin (Montrer INS Anticorps) and IGF-I (Montrer IGF1 Anticorps) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor tyrosine kinase
, tyrosine kinase
, insulin receptor-like
, insulin receptor, beta-subunit