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anti-Human Insulin Receptor Anticorps:
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Human Polyclonal Insulin Receptor Primary Antibody pour IHC (p) - ABIN2479300
Jamner, Shapiro, Goldstein, Hug: Ambulatory blood pressure and heart rate in paramedics: effects of cynical hostility and defensiveness. dans Psychosomatic medicine 1991
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Human Monoclonal Insulin Receptor Primary Antibody pour FACS - ABIN2689096
Soos, OBrien, Brindle, Stigter, Okamoto, Whittaker, Siddle: Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts. dans Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal Insulin Receptor Primary Antibody pour CyTOF, FACS - ABIN4900627
Purushothaman, Babitz, Sanderson: Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. dans The Journal of biological chemistry 2012
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Human Polyclonal Insulin Receptor Primary Antibody pour IF (p), IHC (p) - ABIN671841
Bai, Chen, Liu, Tian, Zhou, Liu, Fang, Chen: Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice. dans Journal of ethnopharmacology 2009
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Human Polyclonal Insulin Receptor Primary Antibody pour FACS - ABIN4897181
Saiya-Cork, Collins, Parkin, Ouillette, Kuizon, Kujawski, Erba, Campagnaro, Shedden, Kaminski, Malek: A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2011
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Human Polyclonal Insulin Receptor Primary Antibody pour FACS - ABIN4897184
Mancini, Gariboldi, Taiana, Bonzi, Craparotta, Pagin, Monti: Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. dans British journal of cancer 2014
Human Polyclonal Insulin Receptor Primary Antibody pour WB - ABIN4226906
Cappuzzo, Toschi, Tallini, Ceresoli, Domenichini, Bartolini, Finocchiaro, Magrini, Metro, Cancellieri, Trisolini, Crino, Bunn, Santoro, Franklin, Varella-Garcia, Hirsch: Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib. dans Annals of oncology : official journal of the European Society for Medical Oncology 2006
They retained the main IGF-1R-related properties, but the hormones with His49 in IGF-1 and His48 in IGF-2 showed significantly higher affinities for IR-A and for IR-B, being the strongest IGF-1- and IGF-2-like binders of these receptors ever reported.
MARCH1 (Montrer MARCH1 Anticorps) ubiquitinates INSR to decrease cell surface INSR levels, but unlike other INSR ubiquitin ligases, MARCH1 (Montrer MARCH1 Anticorps) acts in the basal state rather than after insulin (Montrer INS Anticorps) stimulation.
single-particle cryo-electron microscopy reconstructions of the 1:2 (4.3 A) and 1:1 (7.4 A) complexes of the insulin receptor ECD (Montrer SHFM1 Anticorps) dimer with insulin (Montrer INS Anticorps)
we aim to provide an overview of the physiological and pathophysiological roles of the IR within metabolic syndrome and its related pathologies, including cardiovascular health, gut (Montrer GUSB Anticorps) microflora composition, gastrointestinal tract functioning, polycystic ovarian syndrome, pancreatic cancer, and neurodegenerative disorders
In vitro results show that glycation of INSR decreases insulin (Montrer INS Anticorps) binding under hyperglycemic conditions suggesting this mechanism may provide a mechanism by which INS (Montrer INS Anticorps) resistance develops in diabetes.
Circulating pri-miRNA-944 and 3662 can improve non-invasive non-small cell lung cancer detection of operable stages of SCC (Montrer CYP11A1 Anticorps) and AC
current data demonstrate that both INSR and IGF1R (Montrer IGF1R Anticorps) are directly targeted by C-myc (Montrer MYC Anticorps) and exert similar effects to promote the tumorigenesis and metastasis of TSCC through the NF-kappaB (Montrer NFKB1 Anticorps) pathway.
the mechanism by which insulin (Montrer INS Anticorps) induces IR translocation to the cell nucleus, was examined.
We conclude that the crosstalk between angiotensin AT1 receptor (Montrer AGTRAP Anticorps) and insulin receptor signaling shows a high degree of specificity, and involves Galphaq (Montrer GNAQ Anticorps) protein, and activation of distinct kinases. Thus, the BRET (Montrer DNER Anticorps)(2) technique can be used as a platform for studying molecular mechanisms of crosstalk between insulin receptor and 7TM receptors.
INSR rs1051690 SNP is associated with increased risk of gastric cancer, while polymorphisms in IL12B (Montrer IL12B Anticorps), CCND1 (Montrer CCND1 Anticorps) and IL10 (Montrer IL10 Anticorps) genes are not linked with the presence of gastric cancer
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin (Montrer INS Anticorps)/InsR and IGF-1 (Montrer IGF1 Anticorps)/IGF-1R (Montrer IGF1R Anticorps) signaling. Insulin (Montrer INS Anticorps) therapy in the early stage may delay diabetic gastroparesis
in beta cells, INSR-B has a protective role, while INSR-A expression sensitizes beta cells to programmed cell death.
we show that glucagon receptor (GCGR (Montrer GCGR Anticorps)) inhibition with a monoclonal antibody normalized blood glucose and beta-hydroxybutyrate levels. Insulin receptor antagonism increased pancreatic beta-cell mass threefold. Normalization of blood glucose levels with GCGR (Montrer GCGR Anticorps)-blocking antibody unexpectedly doubled beta-cell mass relative to that observed with S961 alone and 5.8-fold over control
Data (including data from studies in knockout mice) suggest double knockout (DKO) mice lacking Insr and Igf1r (Montrer IGF1R Anticorps) exhibit obesity with insulin (Montrer INS Anticorps) resistance and increased adiposity; on high-fat diet, DKO mice exhibit metabolic syndrome. (Insr = insulin receptor; Igf1r (Montrer IGF1R Anticorps) = insulin-like growth factor I receptor (Montrer IGF1R Anticorps))
The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.
long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.
the overlap of IR and IGF1R (Montrer IGF1R Anticorps) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (Montrer FOXO3 Anticorps)-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (Montrer PRKCE Anticorps) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (Montrer INS Anticorps) resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP (Montrer AGRP Anticorps) neurons (AgRP (Montrer AGRP Anticorps) IR KO) exhibited impaired hepatic insulin (Montrer INS Anticorps) action because the ability of insulin (Montrer INS Anticorps) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (Montrer INS Anticorps) to suppress lipolysis was unaltered. To the contrary, in POMC (Montrer POMC Anticorps) IR KO mice, insulin (Montrer INS Anticorps) lowered hGP but failed to suppress adipose tissue lipolysis.
This FMRP (Montrer FMR1 Anticorps) activity is mediated solely via a second conserved RNA-binding protein, LIN-28 (Montrer LIN28A Anticorps), known to boost insulin (Montrer INS Anticorps) signaling in stem cells. Via LIN-28 (Montrer LIN28A Anticorps), FMRP (Montrer FMR1 Anticorps) controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR).
Impairment of insulin (Montrer INS Anticorps) signalling in the mushroom body neurons, a structure involved in associative learning, impairs feeding behaviour in the Drosophila larva.[Insulin (Montrer INS Anticorps)]
it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals.
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL (Montrer CTSA Anticorps) biosynthesis, prevents inappropriate activation of insulin (Montrer INS Anticorps) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (Montrer IGF1 Anticorps), IGF-2, IGFBP-2 (Montrer IGFBP2 Anticorps), IGFBP-3 (Montrer IGFBP3 Anticorps), IGF-1R (Montrer IGF1R Anticorps), IGF-2R, GHR (Montrer GHR Anticorps), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH (Montrer BRD2 Anticorps), but not E2, stimulated the expression of IR and GHR (Montrer GHR Anticorps) genes during follicular development.
Data conclude that insulin (Montrer INS Anticorps) and IGF-I (Montrer IGF1 Anticorps) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor tyrosine kinase
, tyrosine kinase
, insulin receptor-like
, insulin receptor, beta-subunit