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Human CHEK1 Protein expressed in Baculovirus infected Insect Cells - ABIN457519
Larsen, Rampalli, Burns, Brunette, Dilworth, Megeney: Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks. dans Proceedings of the National Academy of Sciences of the United States of America 2010
Chk1 and 14-3-3 (Montrer YWHAQ Protéines) proteins cooperate to inactivate the transcriptional repressor functions of atypical E2F (Montrer E2F1 Protéines) proteins. This mechanism might be of particular importance to cancer cells, since they are exposed frequently to DNA-damaging therapeutic reagents.
Study provides evidence that expression of CHEK1 protein is high in breast tumors arising in Nigerian women and is associated with aggressive cancer phenotypes and is a prognostic marker.
This study reports the crystal structure of the human Chk1 putative kinase-associated 1 (KA1 (Montrer GRIK4 Protéines)) domain, demonstrating striking structural homology with other sequentially diverse KA1 (Montrer GRIK4 Protéines) domains. Separately purified Chk1 kinase and KA1 (Montrer GRIK4 Protéines) domains are intimately associated in solution, which results in inhibition of Chk1 kinase activity.
The nuclear transcription factor Y subunit beta (NFYB (Montrer NFYB Protéines))-E2F transcription factor 1 (E2F1 (Montrer E2F1 Protéines)) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC (Montrer CALR Protéines)) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC (Montrer CALR Protéines).
Blocking apoptosis alone is insufficient to allow the subsequent outgrowth of primary B cells lacking CHK1 in vivo or B lymphoma lines in vitro, as these cells trigger p53- dependent cell cycle arrest in response to the accumulating DNA damage.
Chk1 and Chk2 (Montrer CHEK2 Protéines) are significantly expressed in human sperm. In case of sperm DNA damage, up-regulated Chk1 expression may enhance sperm apoptosis and lead to asthenospermia, while increased Chk2 (Montrer CHEK2 Protéines) expression may inhibit spermatogenesis and result in oligospermia.
CHK1 and CHK2 (Montrer CHEK2 Protéines) and their activated forms are frequently expressed in HGSC effusions, with higher expression following exposure to chemotherapy, and their expression is related to survival.
expression of AURKA (Montrer AURKA Protéines) and CHEK1 was linked with detrimental outcome in patients. Our data describe a synthetic lethality interaction between CHEK1 and AURKA (Montrer AURKA Protéines) inhibitors with potential translation to the clinical setting
DNA alkylation damage leads to ATR (Montrer ANTXR1 Protéines)-Chk1 activation in cancer cells and ATR (Montrer ANTXR1 Protéines)-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage.
Expression levels of phosphorylated cdc25A (p-cdc25A) and phosphorylated Chk1 (p-Chk1), belonging to the ATR pathway, were decreased by treatment with Dclk1 inhibitor LRRK2-IN-1 (LRRK), indicating Dclk1 involvement in the ATR pathway
Inhibition of Drf1 (Montrer DBF4B Protéines) is the primary mechanism by which Chk1 blocks cell-cycle progression in the early embryo and is an essential function of Chk1 at the blastula-to-gastrula stage of development.
The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.
ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.
Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (Montrer CDC45 Protéines) onto chromatin and thereby serves to antagonize the initiation of replication.
The MRN complex, in particular the nuclease (Montrer DCLRE1C Protéines) activity of Mre11 (Montrer MRE11A Protéines), plays an important role in the activation of Chk1 in response to stalled replication forks.
DNA polymerase kappa (Montrer POLK Protéines)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.
APE2 (Montrer APEX2 Protéines) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (Montrer APEX2 Protéines) is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 (Montrer APEX2 Protéines) in ATR-Chk1 signaling.
Data show that the death pathway is independent of ERK (Montrer MAPK1 Protéines) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (Montrer CDK1 Protéines) and JNK (Montrer MAPK8 Protéines).
Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (Montrer TRH Protéines)(16) by Chk1.
mechanism of Chk1 activation at the DNA replication checkpoint
CHK1 expression levels control the timing of lymphomagenesis
During neurogenesis, cortical neurons became protected from S-phase Chk1 pathway activation by the DNA methyltransferase (Montrer DNMT1 Protéines) Dnmt1 (Montrer DNMT1 Protéines), and underwent cell death after S-phase progression.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (Montrer TRAF1 Protéines)/NF-kappaB (Montrer NFKB1 Protéines)-regulated apoptosis and the p53 (Montrer TP53 Protéines)/PCNA (Montrer PCNA Protéines)- and ATM (Montrer ATM Protéines)/ATR-Chk1/2-controlled DNA-damage response pathways.
Chk1(-/-) MEFs exhibited the absence of double-strand breaks, yet cells showed delayed DNA damage recovery with pan-nuclear immunostaining pattern of Histone H2AX.
RAD9 (Montrer RAD9A Protéines) has a prominent role in the ATR-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
Acute inactivation of E4F1 (Montrer E4F1 Protéines) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (Montrer ROS1 Protéines) production, energy stress, and inhibition of de novo pyrimidine synthesis
Altogether, our results classify E4F1 (Montrer E4F1 Protéines) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.
Heterozygous loss of Chk1 in a Wnt (Montrer WNT2 Protéines)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.
PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity
ATM (Montrer ATM Protéines) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.
The Chk1 directly phosphorylates eNOS (Montrer NOS3 Protéines) Ser (Montrer SIGLEC1 Protéines)(1179) in response to UV irradiation, which is dependent on Hsp90 (Montrer HSP90 Protéines) interaction.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
CHK1 checkpoint homolog
, Serine/threonine-protein kinase Chk1-like protein
, serine/threonine-protein kinase Chk1
, serine/threonine-protein kinase chk1
, Checkpoint, S. pombe, homolog of, 1
, cell cycle checkpoint kinase
, checkpoint kinase-1
, Chk1 checkpoint kinase
, checkpoint kinase 1 homolog
, rad27 homolog
, integral membrane protein 1