CHEK1 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes CHEK1 Protéines
- CHEK1 (Checkpoint Kinase 1 (CHEK1))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 3
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CHEK1 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human CHK1 (transcript variant 3) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CHEK1 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- CHEK1 (Checkpoint Kinase 1 (CHEK1))
- Autre désignation
- Chk1 (CHEK1 Produits)
- Synonymes
- An08g10320 Protein, AO090003000441 Protein, CHK1 Protein, chk1 Protein, C85740 Protein, Chk1 Protein, rad27 Protein, id:ibd2720 Protein, zgc:56093 Protein, CHEK1 Protein, checkpoint kinase 1 Protein, serine/threonine-protein kinase chk1 Protein, serine/threonine-protein kinase Chk1 Protein, CAMK/CAMKL/CHK1 protein kinase Chk1 Protein, checkpoint kinase 1 S homeolog Protein, CHEK1 Protein, ANI_1_2436074 Protein, AOR_1_768154 Protein, PTRG_04183 Protein, SJAG_01680 Protein, PAAG_04978 Protein, MCYG_03290 Protein, VDBG_03742 Protein, chek1.S Protein, Chek1 Protein, chek1 Protein
- Sujet
- The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
- Poids moléculaire
- 54.3 kDa
- NCBI Accession
- NP_001107594
- Pathways
- Signalisation p53, Apoptose, Cycle Cellulaire, Réparation de l'ADN
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