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results provide new insights into EGR-1 (Montrer EGR1 Protéines)/ASPP1 regulatory loop in sensitizing Quercetin-induced apoptosis. EGR-1 (Montrer EGR1 Protéines)/ASPP1, therefore, may be potentially used as therapeutic targets to improve cancer's response to pro-apoptosis treatments.
Results showed that the protein expression levels of ASPP1 in esophageal squamous cell carcinoma (ESCC) tissues and in paired noncancerous tissues were similar but was significantly associated with histological differentiation and invasive depth which suggest that it might be involved in the progression of ESCC.
Increased expression of p53 (Montrer TP53 Protéines) and ASPP1 and downregulation of iASPP (Montrer PPP1R13L Protéines).
ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.
ASPP1/2 interacted with centrosome linker protein C-Nap1. Co-depletion of ASPP1 and ASPP2 inhibited re-association of C-Nap1 with centrosome at the end of mitosis.
ASPP1 and ASPP2 (Montrer TP53BP2 Protéines) cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53 (Montrer TP53 Protéines).
When the Px(T)PxR (Montrer NR1I2 Protéines) motif is deleted or mutated via insertion of a phosphorylation site mimic (T311D), PP-1c fails to bind to all three ASPP proteins, ASPP1, ASPP2 (Montrer TP53BP2 Protéines) and iASPP (Montrer PPP1R13L Protéines).
the mRNA expression of ASPP1 and ASPP2 (Montrer TP53BP2 Protéines) was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 (Montrer TP53 Protéines)
ASPP1 promoter methylation may be associated with the malignant progression of non-small cell lung cancer, and ASPP1 expression promotes cellular apoptosis.
The ability of ASPP1 to activate YAP (Montrer YAP1 Protéines) results in the decreased expression of LATS2, which lowers the ability of p53 (Montrer TP53 Protéines) to induce p21 (Montrer CDKN1A Protéines), cell-cycle arrest and senescence.
After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC (Montrer FUT1 Protéines)) cycling and induces p53 (Montrer TP53 Protéines)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC (Montrer FUT1 Protéines) self-renewal and accumulation of DNA damage in p53 (Montrer TP53 Protéines) null HSCs.
Our study demonstrates a novel role for ASPP1 and ASPP2 (Montrer TP53BP2 Protéines) in the death of retinal ganglion cells.
Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53 (Montrer TP53 Protéines)-independent manner.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
apoptosis-stimulating of p53 protein 1
, apoptosis-stimulating protein of p53, 1
, protein phosphatase 1 regulatory subunit 13B
, protein phosphatase 1, regulatory (inhibitor) subunit 13B
, apoptosis-stimulating protein of p53
, apoptosis-stimulating of p53 protein 1-like
, transformation related protein 53 binding protein 2
, tumor protein p53 binding protein, 2
, tumor protein p53-binding protein, 2