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Human Neuregulin 4 Protein expressed in - ABIN1111850
McElroy, Castle, Bernard, Almohazey, Hunter, Bell, Al Alam, Wang, Ford, Frey: The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. dans The American journal of pathology 2016
Show all 3 Pubmed References
Human Neuregulin 4 Protein expressed in Wheat germ - ABIN1313026
Liu, Tefft, Roberts, Zhang, Ren, Li, Huang, Zhang, Phillips, Wu: Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. dans American journal of physiology. Heart and circulatory physiology 2012
Nrg4 has a role in maintaining systemic metabolic homeostasis at least partially through enhancing adipose tissue angiogenesis
Study reported for the first time that circulating Nrg4 concentrations were significantly reduced in patients with coronary artery disease (CAD) and Nrg4 levels were lower in the patients with a higher SYNTAX score. These findings indicated that Nrg4 levels were inversely associated with the presence and severity of CAD.
Nrg4 is highly and preferentially expressed in healthy adipocytes, while its expression was substantially reduced in obesity. Nrg4 activated endothelial angiogenic functions and angiogenesis both in vitro and in vivo.
Serum NRG4 values were significantly elevated in the Gestational Diabetes Mellitus (GDM) group compared to the control group and is associated with metabolic parameters of GDM.
circulating Nrg4 concentrations are inversely associated with subclinical atherosclerosis in obese adults; circulating Nrg4 might play a role in identifying patients at high risk for cardiovascular disease
The circulating Nrg4 level is elevated in the prediabetic and diabetic patients compared to control and is an independent risk factor associated with diabetes.
High serum Nrg4 levels are associated with type 2 diabetes mellitus.
NRG4 and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC.
Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD).
results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).
Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival
The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4.
NRG4 overexpression is associated with advanced-stage prostate cancer
describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide
NRG4 was positive in almost all breast cancers studied.
Neuregulin-4 expression is downregulated during urinary bladder cancer progression
hepatic Nrg4 signaling serves as an endocrine checkpoint for steatosis-to-NASH progression by activating a cytoprotective pathway to counter stress-induced liver injury.
This study demonstrates for the first time that hepatic Nrg4 plays an important role in the regulation gluconeogenesis in vitro and in vivo. Nrg4 knockdown in liver attenuates enhanced hepatic gluconeogenesis in db/db mice via suppressing PEPCK, G6Pase, and PGC-1alpha expressions.
The found of this study showed that NRG4 is a major novel regulator of dendritic arborisation in the developing cerebral cortex and suggest that it exerts its effects by an autocrine/paracrine mechanism.
Conditional knockout of Nrg4 in brown adipocytes caused blood vessel reduction in brown but not in white adipose tissue , and was sufficient to induce obese phenotype.
Nrg4 exerts beneficial effects on energy balance and glucose and lipid metabolism to ameliorate obesity-associated metabolic disorders.
overexpression of the Nrg4 gene by hydrodynamic gene delivery prevents high fat diet-induced weight gain and fatty liver, alleviates obesity-induced chronic inflammation and insulin resistance
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR\; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999
, pro-neuregulin-4, membrane-bound isoform
, heregulin 4