Neuregulin 4 Protein (NRG4) (AA 2-62) (His tag)

N° du produit ABIN2870671

Détail du produit

Antigène: Neuregulin 4 (NRG4)

Type de proteíne: Recombinant

Attributs du protein: AA 2-62

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Neuregulin 4 protéine est marqué à la His tag.

Séquence: AA 2-62

Attributs du produit: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 8.6 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM NaCl, pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: Neuregulin 4 (NRG4)

Autre désignation: Neuregulin-4 (NRG4 Produits)

Synonymes: HRG4 Protein, AI552600 Protein, neuregulin 4 Protein, NRG4 Protein, Nrg4 Protein, LOC100347220 Protein

Sujet: Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation. Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.

Poids moléculaire: 8.6 kDa

UniProt: Q8WWG1

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway