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ELP2 mutation is implicated in severe intellectual disability, spastic diplegia, and self-injurious behavior described in two brothers.
Studied the possible relationship between STATIP1, STAT3 and CML resistance.
Elp2 and STAT-3 (Montrer STAT3 Anticorps) mediate, at least in part, the stimulation of Hsp70 (Montrer HSP70 Anticorps) expression by 4PBA.
Elp2 role in the development of the ureter obstruction induced renal fibrosis.Elp2 regulates Stat3 (Montrer STAT3 Anticorps) and TGF-beta1 (Montrer TGFB1 Anticorps) and NF-kappa B (Montrer NFKB1 Anticorps) pathways in the renal fibrosis.
Targeting ELP2 activity as a novel therapeutic option to limit the inhibition of osteoblast differentiation by inflammatory microenvironment.
US28 induces proliferation in HCMV-infected tumors by establishing a positive feedback loop through activation of the IL-6 (Montrer IL6 Anticorps)-STAT3 (Montrer STAT3 Anticorps) signaling axis.
STAT3 (Montrer STAT3 Anticorps) interacts with STRA13 (Montrer STRA13 Anticorps) and modulates transcription of STAT3 (Montrer STAT3 Anticorps)-dependent targets.
Data show that HMGA1a (Montrer HMGA1 Anticorps) binding activity in nuclear fractions from murine retina, but not from hippocampus, resulted in STAT3 interacting protein 1 (StIP1) that formed a novel complex with HMGA1a (Montrer HMGA1 Anticorps), STAT3 (Montrer STAT3 Anticorps) and homeodomain-interacting protein kinase 2 (HIPK2 (Montrer HIPK2 Anticorps)).
ELP2 positively contributes to resistance to the necrotrophic fungal pathogens Botrytis cinerea and Alternaria brassicicola.
The elp2 mutant had accelerated differentiation of root stem cells and cell division was more active in its quiescent centre (QC); the key transcription factors responsible for maintaining root stem cell and QC identity were all strongly down-regulated.
ELP2 plays an evolutionarily conserved role in DNA demethylation/methylation in plants and likely functions as an epigenetic regulator of plant immune responses.
AtELP2 is an accelerator of defense gene induction, which functions largely independently of NPR1 in establishing plant immunity.
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). Promotes organs development by modulating cell division rate. Prevents abscisic acid (ABA) signaling leading to stomatal closure and seedling growth inhibition. Involved in oxidative stress signaling. Prevents anthocyanins accumulation. Accelerator of defense gene induction required for rapid defense gene induction, and for the establishment of both basal and effector-triggered immunity (ETI), in a NPR1-independent manner, but is not required for systemic acquired resistance (SAR) establishment.
elongator complex protein 2
, STAT3-interacting protein 1
, elongation protein 2 homolog
, elongator protein 2
, signal transducer and activator of transcription 3 interacting protein 1
, signal transducer and activator of transcription interacting protein 1