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Human Polyclonal DDH Primary Antibody pour WB - ABIN514921
Ebert, Kisiela, Wsól, Maser: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. dans Chemico-biological interactions 2011
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Human Polyclonal DDH Primary Antibody pour ELISA, WB - ABIN560581
Buytaert, Matroule, Durinck, Close, Kocanova, Vandenheede, de Witte, Piette, Agostinis: Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. dans Oncogene 2008
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Decreased invasion caused by AKR1C1 knockdown suggests a novel role of AKR1C1 in cancer invasion, which is probably due to the regulation of Rac1 (Montrer RAC1 Anticorps), Src (Montrer SRC Anticorps), or Akt (Montrer AKT1 Anticorps). An inflammatory cytokine, interleukin-1beta, was found to increase AKR1C1 in bladder cancer cell lines.
Data show that increased levels of AKR1C1/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB).
the present study suggests that AKR1C1, AKR1C2 (Montrer AKR1C2 Anticorps), AKR1C3 (Montrer AKR1C3 Anticorps), and AKR1C4 (Montrer AKR1C4 Anticorps) are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
Activation of AKR1C1/ERbeta (Montrer ESR2 Anticorps) induces apoptosis by downregulation of c-FLIP (Montrer CFLAR Anticorps) in prostate cancer cells.
results suggest a gender-specific modulatory effect of AKR1C1 on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain
Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 (Montrer AKR1C4 Anticorps) are responsible for sexual development dysgenesis and mutations in AKR1D1 (Montrer AKR1D1 Anticorps) are causative in bile-acid deficiency.
activation of the Nrf2 (Montrer GABPA Anticorps)/AKR1C axis may contribute to oxaliplatin resistance in gastric carcinoma
The involvement of up-regulated AKR1C1, AKR1C3 (Montrer AKR1C3 Anticorps) and proteasome in CDDP resistance of colon cancers.
Which promoted significant reduction of AKR1C1 and AKR1C2 (Montrer AKR1C2 Anticorps) expression.
Data suggest that interleukin-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of AKR1C1 and AKR1C2 (Montrer AKR1C2 Anticorps).
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
20 alpha-hydroxysteroid dehydrogenase
, 20-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase C
, aldo-keto reductase family 1 member C1
, chlordecone reductase homolog HAKRC
, dihydrodiol dehydrogenase 1
, dihydrodiol dehydrogenase 1/2
, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
, dihydrodiol dehydrogenase isoform DD1
, hepatic dihydrodiol dehydrogenase
, high-affinity hepatic bile acid-binding protein
, indanol dehydrogenase
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, type II 3-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase family 1 member C1 homolog