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OPSCC with integrated HPV16 show upregulation of AKR1C1 and AKR1C3 expression.
AKR1C1 activates STAT3 pathway to promote NSCLC metastasis.
Decreased invasion caused by AKR1C1 knockdown suggests a novel role of AKR1C1 in cancer invasion, which is probably due to the regulation of Rac1, Src, or Akt. An inflammatory cytokine, interleukin-1beta, was found to increase AKR1C1 in bladder cancer cell lines.
Data show that increased levels of AKR1C1/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB).
the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
Activation of AKR1C1/ERbeta induces apoptosis by downregulation of c-FLIP in prostate cancer cells.
results suggest a gender-specific modulatory effect of AKR1C1 on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain
Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency.
activation of the Nrf2/AKR1C axis may contribute to oxaliplatin resistance in gastric carcinoma
The involvement of up-regulated AKR1C1, AKR1C3 and proteasome in CDDP resistance of colon cancers.
Which promoted significant reduction of AKR1C1 and AKR1C2 expression.
Data suggest that interleukin-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of AKR1C1 and AKR1C2.
It was concluded that the truncated E6 protein of human papillomavirus 16, known as E6*I, has a novel function in upregulating expression of human AKR1C.
role of AKR1C1in the metabolism of testosterone and progesterone via the 5beta-reductase pathway.
enhanced metabolism of progesterone by SRD5A1 and the 20alpha-HSD and 3alpha/beta-HSD activities of AKR1C1, AKR1C2 and AKR1C3
analysis of single nucleotide polymorphisms of AKR1C1 and AKR1C2
Functionally expressed human AKR1C1 (20alpha-hydroxysteroid dehydrogenase) in the fission yeast Schizosaccharomyces pombe and demonstrate the ability of the resulting yeast strain to efficiently catalyze the reduction of progesterone or dydrogesterone.
non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors
Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer
Reduction of dihydrodiol dehydrogenase expression is associated with resected hepatocellular carcinoma
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
20 alpha-hydroxysteroid dehydrogenase
, 20-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase C
, aldo-keto reductase family 1 member C1
, chlordecone reductase homolog HAKRC
, dihydrodiol dehydrogenase 1
, dihydrodiol dehydrogenase 1/2
, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
, dihydrodiol dehydrogenase isoform DD1
, hepatic dihydrodiol dehydrogenase
, high-affinity hepatic bile acid-binding protein
, indanol dehydrogenase
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, type II 3-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase family 1 member C1 homolog