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Human CD55 Protein expressed in Human Cells - ABIN2002065
Bergelson, Chan, Solomon, St John, Lin, Finberg: Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses. dans Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 5 Pubmed References
DAF is a potential molecule involving in endometrial cellular proliferation and motility
The work identified two new host factors that may act as receptors for P. falciparum during invasion: CD44 and CD55. (Review)
the first comprehensive analysis of variation in the CD55 gene in the context of Severe malaria.
CD55 rs2564978 polymorphism may contribute to an increased risk of non-small cell lung carcinoma in Chinese population.
HPLC/MS analyses of diabetic RBC glucose-modified DAF localized the sites of AGE modifications to K(125) adjacent to K(126), K(127) at the junction of CCPs2-3 and spatially near R(96), and R(100), all identified as being critical for DAF's function. Non-enzymatic DAF glycation de-regulated activation of systemic complement and T-cell activation.
CD55 TT genotype was linked to H7N9/H1N1pdm09 influenza severity in a large Chinese cohort.
our data show that hepatitis C virus (HCV) infection induces sCD55 expression in HCV-infected cell culture-conditioned medium and inhibits C3 convertase activity
CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (the CHAPLE syndrome) is caused by abnormal complement activation due to biallelic loss-of-function mutations in CD55.
This study demonstrates an up-regulation of complement regulatory proteins, CD35 and CD55 in HIV associated pre-eclamptic compared to normotensive pregnancy.
There is an altered pattern of CD55 and CD59 expression on RBCs of SCD Patients; however, it does not seem to play a causal role in the pathophysiology of anemia, and is unlikely to be influenced by the level of erythropoietin or other inflammatory mediators.
This study indicated that the CD97 and CD55 proteins might be reliable biomarkers to predict the metastasis status and prognosis of intrahepatic cholangiocarcinoma patients.
Expression of PBMC-DAF declined in patients both at mRNA and surface level and correlated negatively with the disease activity. Expression of IFN-gamma also declined in patients but correlated positively with DAF and negatively with disease activity
Over expression of CD55 in brushing samples taken from Barrett's esophagus
present study suggested that the expressions of CD97 antigen and decay accelerating factor DAF were both upregulated in human cervical squamous cell carcinoma
conclude that CD55 expression is affected by glycemic status in human islets and plays a critical role in maintaining the conserved structure of rafts in pancreatic islets, which is similar to that of the related complement inhibitor CD59
CD55 is an essential host factor for P. falciparum invasion. CD55-null erythrocytes were refractory to invasion by all isolates of P. falciparum because parasites failed to attach properly to the erythrocyte surface.
Data suggest that CD55 (but not CD59) on red blood cells is down-regulated in subjects with beta-thalassemia major as compared to control subjects; CD55 expression is intermediate on patients with beta-thalassemia intermedia.
Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate coxsackievirus B3 infection by the enteral route.
Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy.
Taken together, these results support the current model of coxsackievirus B3-DAF interaction and point to a specific role for viral VP1 T271 and DAF S104 at the virus-DAF interface.
CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.
regulates self-renewal and cisplatin resistance in endometrioid tumors
Results show that definitive endoderm (DE) expressing Daf1 are slowly proliferating and adhesive cells suggesting that Daf1 is a marker of late stage DE.
these data show a key role for HIF-1alpha in regulating the expression of CD55 on airway epithelium.
CD55 is produced by the synovium and deposited on local collagen fiber meshwork, where it protects against immune complex-mediated arthritis.
Fibrosis in Daf1-/- mice was accompanied by high expression of alpha-smooth muscle actin.
the downregulation of CD55 expression precedes, and has an important role regarding, the activation of C3 in the occurrence and development of DNP.
IFN-gamma-producing NKT cells enhance C5a generation via IL-10-mediated inhibition of CD55 expression on neutrophils, thereby exacerbating sepsis.
CD55 downregulates CD97 surface expression on circulating leukocytes by a process that requires physical forces.
Trypanosoma cruzi-inoculated DAF-deficient mice provide a useful model for studying T-cell mediated immunity in skeletal muscle tissues.
Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 or CD59 showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor antibodies, and more complement deposition at the neuromuscular junction.
These data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense.
Complement dysregulation in the absence of CD55 provoked increased C3adesArg production that, in turn, caused altered lipid handling, resulting in atheroprotection and increased adiposity.
DAF suppressed T-cell immunity as a complement regulator in the context of inflammation but did not play an intrinsic role on T cells or antigen-presenting cells
These data suggest an intriguing effect of reduced DAF expression on host responses following in vivo mouse cytomegalovirus infection.
Murine cytomegalovirus infection augments morbidity and mortality post-allo-bone marrow transplantion by reducing surface DAF expression.
DAF1 expression is maintained until differentiation day 12 in ES cell-derived definitive endoderm cells.
DAF has a role in conferring ocular immune privilege for successful corneal engraftment
These findings demonstrate that the absence of Daf1 exacerbates IFN-gamma-dependent murine mercury-induced autoimmunity (mHgIA), with changes in the profile of expressed cytokines.
Decay-accelerating factor control of C3a and C5a generation and prevention of the binding of these activation fragments to the C3a and C5a receptors are critical for the biological response to vascular injury.
This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF)\; binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined.
, complement decay-accelerating factor
, Cromer blood group
, GPI anchor addition signal
, complement decay-accelerating factor, GPI-anchored
, decay accelerating factor 1
, CD55 molecule, decay accelerating factor for complement (Cromer blood group)
, decay-accelerating factor (GDab-TCS)
, decay-accelerating factor CD55
, decay accelarating factor 1
, decay accelerating factor GPI-form
, decay-accelarating factor
, glycosylphophatidylinositol-anchored form
, decay accelerating factor for complement
, decay-accelerating factor 1