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Human Plasminogen (PLG) interaction partners

1. we identified a missense mutation, K330E, in the PLG gene in four patients from two unrelated families with HAEnCI in Japan. To our knowledge, the F12 mutations, as well as other genetic abnormalities, have not been reported in Asian patients.

2. The presence of active plasmin in urine in hydronephrosis could cause abnormal proteolytic activation of ENaC-gamma and impaired ability to excrete Na via NCC.

3. The ability of HMGA1 to regulate the plasminogen activator system may constitute an important mechanism by which HMGA1 promotes cancer progression.

4. Hereditary angioedema with a mutation in the PLG gene is a novel type of hereditary angioedema. It is associated with a high risk of tongue swellings.

5. Here, the authors show that PspC is a pneumococcal plasminogen receptor and that plasmin generated on the surface of hemolytic uremic syndrome pneumococci damages endothelial cells, causing endothelial retraction and exposure of the underlying matrix.

6. This study shows that suppression of PKC-alpha attenuates TNF-alpha-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system.

7. This article gives an update of the current knowledge about the role of the plasminogen activation system on different aspects of neuroinflammation. [review]

8. Apo(a) attenuates cell-surface plasmin-mediated conversion of Glu- to Lys-plasminogen.

9. Urinary angiostatin and VCAM-1 are predictive of specific histological changes in concurrent lupus nephritis renal biopsies.

10. We did not find an association of the AgP risk variant rs4252120 with CP. However, we identified a haplotype block downstream of PLG, which showed shared association with CP and AgP.

11. The homozygous alleles in F12 (rs1801020) and F13 (rs5985) was identified a genetic risk profile of thromboembolism in a Family.

12. Our findings that plasminogen and pSTAT3 are significantly associated with LI suggest that they may represent signaling nodes or biomarkers of pathways common to the processes of postlactational involution and LI.

13. A rare non-conservative missense mutation was newly identified in exon 9 of the PLG gene.

14. Plasminogen binds to the cell surface-exposed proteins of Candida parapsilosis.

15. plasmin cleaves surface-bound CCL21 to release the C-terminal peptide responsible for CCL21 binding to glycosaminoglycans on the extracellular matrix and cell surfaces, thereby generating the soluble form.

16. Analysis of plasminogen genetic variants in multiple sclerosis patients has been reported.

17. Enolase of Mtb is present on its surface and binds human plasminogen with high affinity.

18. Data suggest that protein aggregates interact with tissue-type plasminogen activator and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).

19. The mechanism for plasminogen/M protein binding uncovered here may facilitate targeting of group A Streptococcus pyogenes virulence factors for disease management

20. t-PA binds to Lys91 in the MBP NH2-terminal region and PLG binds to Lys122 in the MBP COOH-terminal region. This proximity promotes the activation of PLG by t-PA.

Cow (Bovine) Plasminogen (PLG) interaction partners

1. SUPA formed a higher avidity complex (118-fold) with bovine Pg than with human Pg and non-proteolytically activated bovine but not human Pg.

2. The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.

3. The current study suggests the existence of an active TNF-alpha-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows.

4. examination of interaction with streptococcal plasminogen activator PauA

Pig (Porcine) Plasminogen (PLG) interaction partners

1. The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.

Mouse (Murine) Plasminogen (PLG) interaction partners

1. These studies suggest a crucial role for peripheral PL in mediating neuroimmune cell activation and Alzheimer's disease (AD) progression and could provide a link to systemic inflammatory risk factors that are known to be associated with AD development.

2. Variation in blood plasminogen levels, within the range seen in normal individuals, had marked effects on experimental ischemic brain injury

3. plasmin protease activity prevents dystrophic calcification within injured skeletal muscle independent of its canonical fibrinolytic function.

4. Plasminogen-deficient mice have extensive fibrin and neutrophil depositions in the wounded area long after re-epithelialisation, indicating inefficient debridement and chronic inflammation. Delayed formation of granulation tissue suggests that fibroblast function is impaired in the absence of plasminogen.

5. confirmed the ability of Plg/Pla to both promote efferocytosis and override the prosurvival effect of LPS via annexin A1.

6. findings identify plasmin as a decisive checkpoint in the inflammatory response during Macrophage activation syndrome (MAS) and a potential novel therapeutic target for MAS.

7. Deficiency of plasminogen delays onset of autoimmune neuroinflammatory disease and protects from the development of paralysis.

8. Plasminogen may regulate DPP-4 activity and glucose metabolism.

9. Plasminogen-deficient mice frequently develop colon lesions and rectal prolapses.

10. manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein

11. Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.

12. plg-/- and tPA-/- mice exhibit brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity

13. plasminogen-dependent proteolysis has a beneficial effect during neurological recovery after stroke.

14. Pla-induced mononuclear cell recruitment in vivo was dependent on protease-activated receptor-1 activation of the MEK/ERK/NF-kappaB pathway, which led to the release of CCL2 and activation of CCR2.

15. Plg may play an important role in innate immunity by changing expression of genes that contribute to phagocytosis.

16. Plasminogen is a key molecular determinant of inflammatory joint disease capable of simultaneously driving or ameliorating arthritis pathogenesis in distinct anatomic locations in the same subject.

17. Plasmin suppresses brain metastasis in two ways: by converting membrane-bound astrocytic FasL into a paracrine death signal for cancer cells, and by inactivating the axon pathfinding molecule L1CAM, which metastatic cells express for spreading along brain capillaries and for metastatic outgrowth.

18. Plasminogen stimulates autocrine cytokine production in human airway smooth muscle cells in a manner mediated by plasmin and annexin A2.

19. plasminogen contributes to angiogenesis related to macrophage accumulation, TGF-beta, and VEGF, thereby leading to the enhancement of bone repair.

20. These findings highlight a critical role for plasmin in the catabolism of aggregated LDL by macrophages and provide a new context for considering the atherogenic role of plasmin.