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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. dans Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1 (Montrer AFT1 Protéines), and ATF3 (Montrer ATF3 Protéines) during gastrulation.
This study showed that the induction level of IL-32 (Montrer IL32 Protéines) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (Montrer IRF6 Protéines)-induced IL-32 (Montrer IL32 Protéines) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (Montrer TLR4 Protéines)/JNK (Montrer MAPK8 Protéines)/AKT (Montrer AKT1 Protéines)/CREB signaling pathway.
Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB) protein (CBP (Montrer CREBBP Protéines))/beta-catenin (Montrer CTNNB1 Protéines) or gamma-catenin (Montrer JUP Protéines) interaction.
Study indicates that BPA (Montrer DST Protéines) increases phosphorylated CREB in MCF-7 Cells as well as it binding to SOX2 (Montrer SOX2 Protéines) enhancer.
study concludes that miR-132 regulated SIRT1/CREB/ABCG2 signaling pathway contributing to the cisplatin resistance and might serve as a novel therapeutic target against gastric cancer
Leptin (Montrer LEP Protéines) also significantly increased cAMP levels, cAMP response element (CRE) activation, and CREB phosphorylation.
these data show the existence of functional CREB and C/EBP (Montrer CEBPA Protéines) binding sites in the human RIC8B gene promoter, a particular distribution of these sites and demonstrate a relevant role of CREB in stimulating transcriptional activity of this gene.
MALAT1 knockdown reduces reactive gliosis, Muller cell activation, and RGC survival in vivo and in vitro MALAT1-CREB binding maintains CREB phosphorylation by inhibiting PP2A (Montrer PPP2R4 Protéines)-mediated dephosphorylation, which leads to continuous CREB signaling activation.
aberrant activation of CREB-C/EBPdelta (Montrer CEBPD Protéines) axis concurring to AML (Montrer RUNX1 Protéines) onset by disrupting the myeloid cell differentiation process
miR (Montrer MLXIP Protéines)-27b-3p levels were found to be significantly negatively correlated with both NR5A2 (Montrer NR5A2 Protéines) and CREB1 levels in breast cancer tissues.
Interactions between GNB3 (Montrer GNB3 Protéines), CREB1 and negative life events were revealed. Further evidence is provided about the role of the environment in genetic vulnerability to major depression.
Ca(2 (Montrer CA2 Protéines)+) signaling pathway increases Nr4a1 (Montrer NR4A1 Protéines) expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (Montrer MEF2C Protéines), AP1 (Montrer JUN Protéines), and CREB transcription factors thus demonstrating an important interplay between the Ca(2 (Montrer CA2 Protéines)+) and cAMP pathways in regulating Nr4a1 (Montrer NR4A1 Protéines) expression.
PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway.
study revealed the involvement of CREB in B-1a cells, which was upregulated to increase the production of IL-10 (Montrer IL10 Protéines) for attenuating inflammation and organ injury, and finally improving survival during sepsis
In conclusion, glucocorticoid couples mGR (Montrer GRHL1 Protéines) with Galphas (Montrer GNAS Protéines) and triggers cAMP-PKA-CREB axis dependent on the lipid raft to stimulate BACE1 (Montrer BACE Protéines) upregulation and Abeta (Montrer APP Protéines) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.
CREB was found to bind to GSK3beta promoter and essential for cAMP-mediated regulation of GSK3beta.
The NR2B (Montrer GRIN2B Protéines)-CREB-miR212/132-CRTC1 (Montrer CRTC1 Protéines)-CREB signal network plays an important role in the regulation of pain.
Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI.
Our results elucidate the specific role of the transcription factors CREB, SRF, and MEF2 (Montrer MEF2C Protéines) in the depression and potentiation components of ODP in vivo, therefore better informing future attempts to find therapeutic targets for diseases where activity-dependent plasticity is disrupted.
neuronal activity promotes CREB-dependent transcription by increasing the frequency of CREB binding to highly localized genome locations
Expression of miR (Montrer MLXIP Protéines)-26a or knockdown of Klf4 (Montrer KLF4 Protéines) or Creb or C/ebpbeta (Montrer CEBPB Protéines), attenuated the survival of Mycobacterium tuberculosis in macrophages.
The expression of porcine Prdx6 (Montrer PRDX6 Protéines) gene is up-regulated by C/EBPbeta (Montrer CEBPB Protéines) and CREB.
Results suggest that cerebral hypoxia results in differential regulation of CREB protein-mediated expression of proapoptotic and antiapoptotic proteins in the cerebral cortex of newborn piglets.
Data indicate that Ser738/742-to-glutamate (Montrer GRIN2A Protéines) protein kinase D (Montrer PRKD1 Protéines) mutant increased AngII-induced CREB protein and activating transcription factor 2 (Montrer ATF2 Protéines) phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein (Montrer STAR Protéines) promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 (Montrer LYPLA1 Protéines)
the p38-MAPK (Montrer MAPK14 Protéines)/CREB pathway plays a critical role in TNFalpha (Montrer TNF Protéines)-induced VCAM-1 (Montrer VCAM1 Protéines) expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK (Montrer MAPK14 Protéines) and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK (Montrer MAPK14 Protéines) pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein