Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
Our results provide new insight into the effect of ITK and suboptimal T-cell receptor signaling on CD8 (Montrer CD8A Protéines)(+) T cell function, and how these may contribute to phenotypes associated with ITK deficiency
Data suggest that the pleckstrin homology domain of Itk functions as a phospholipid bilayer recognition site that localizes Itk to membrane via phosphatidylinositol 3,4,5-trisphosphate (PIP3) binding; this specific binding inhibits the phospho-transfer reaction via an allosteric mechanism.
pharmacological inhibition of ITK resulted in T cell hyperplasia and the increased production of TH2-type cytokines.
ITK and BTK (Montrer BTK Protéines) regulate thermal homeostasis during septic response through mast cell function in mice.
Taken together, these data indicate that ITK plus RLK (Montrer TXK Protéines) inhibition may have therapeutic potential in Th1 (Montrer HAND1 Protéines)-mediated inflammatory diseases.
This work has important implications for understanding the role of Itk signaling in the development versus function of iNKT cells, Th1 (Montrer HAND1 Protéines), Th2, and Th17 cells.
The kinase Itk and the adaptor TSAd (Montrer SH2D2A Protéines) change the specificity of the kinase Lck (Montrer LCK Protéines) in T cells by promoting the phosphorylation of Tyr192.
Data indicate that the interleukin-2 (Montrer IL2 Protéines) inducible tyrosine kinase (Montrer TYRO3 Protéines) K390R point mutation (Itk-KD) transgenic mice were largely protected from inflammatory symptoms in an Ovalbumin (Montrer OVA Protéines) model of airway inflammation.
The Itk pleckstrin (Montrer PLEK Protéines) homology domain binds to Calmodulin and PI(3,4,5)Pto promote efficient calcium signaling and IL-17A (Montrer IL17A Protéines) production.
Signaling by Itk promotes autoimmunity and CNS inflammation.
These observations have significant therapeutic implications, as pharmacologic inhibition of ITK prevented the activation of this signaling axis and overcame chemotherapy resistance.
The data indicate that increased ITK expression could act as a disease activity marker and as a risk factor for involvement in SLE, but it still needs further study to confirm.
We conclude that ITK, formerly considered an immune cell-specific protein, is aberrantly expressed in melanoma and promotes tumor development and progression
Found that 38% and 14% of the Angioimmunoblastic T-cell lymphoma cases exhibited gains of ITK and SYK (Montrer SYK Protéines) genes, respectively.
These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK (Montrer TXK Protéines), and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.
approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR (Montrer EGFR Protéines) in EGFR (Montrer EGFR Protéines)-dependent PC9 (Montrer PCSK9 Protéines) cells, and these genes include seven of nine Src (Montrer SRC Protéines) family kinase genes, FGFR1 (Montrer FGFR1 Protéines), FGFR2 (Montrer FGFR2 Protéines), ITK, NTRK1 (Montrer NTRK1 Protéines), NTRK2 (Montrer NTRK2 Protéines), MOS (Montrer MOS Protéines), MST1R (Montrer MST1R Protéines), and RAF1 (Montrer RAF1 Protéines).
ITK deficiency is a genetic cause of idiopathic CD4 (Montrer CD4 Protéines)+ T-cell lymphopenia.
Data indicate reduced T-cell activation by altered IL-2 inducible T-cell kinase (ITK) expression in vitro.
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
, interleukin-2-inducible T cell kinase
, kinase TLK
, tyrosine-protein kinase ITK/TSK
, IL-2-inducible T cell kinase
, IL-2-inducible T-cell kinase
, homolog of mouse T-cell itk/tsk
, interleukin-2-inducible T-cell kinase
, kinase EMT
, tyrosine-protein kinase LYK