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MALT1 and TRAF6 (Montrer TRAF6 Protéines) cooperatively interact with CARMA1 (Montrer CARD11 Protéines)-BCL10 (Montrer BCL10 Protéines) filaments and form CARMA1 (Montrer CARD11 Protéines)-BCL10 (Montrer BCL10 Protéines)-MALT1-TRAF6 (Montrer TRAF6 Protéines) signalosome.
The results suggest that the involvement of MALT1 in DNA damage-induced NF-kappaB (Montrer NFKB1 Protéines) is through the recruitment of TRAF6 (Montrer TRAF6 Protéines).
A missense mutation in mucosa-associated lymphoid tissue lymphoma translocation 1 gene (MALT1) was identified in a family with siblings with IPEX (Montrer FOXP3 Protéines)-Like Syndrome. MALT1 deficiency should now be considered as a possible cause of IPEX (Montrer FOXP3 Protéines)-like syndrome associated with immunodeficiency.
Thrombin (Montrer F2 Protéines)-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD (Montrer CYLD Protéines) cleavage.
Authors utilized transcriptomic data and experimental evidences to prove that miR (Montrer MLXIP Protéines)-181d was a novel regulator of NFkappaB (Montrer NFKB1 Protéines) signaling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES (Montrer ME1 Protéines) genes.
Taken together, this present study indicates that miR (Montrer MLXIP Protéines)-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies.
These results demonstrate a key role for the proteolytic activity of MALT1 in PEL, and provide a rationale for the pharmacological targeting of MALT1 in PEL therapy.
MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14 (Montrer CARD14 Protéines)-induced cytokine and chemokine (Montrer CCL1 Protéines) expression in human primary keratinocytes.
results unveil HOIL1 (Montrer RBCK1 Protéines) as a negative regulator of lymphocyte activation cleaved by MALT1.
CARD14 (Montrer CARD14 Protéines)/MALT1-mediated signaling in keratinocytes has a role in psoriasis [review]
IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets.
this study shows that Malt1 protease activity plays an important role in the activation of innate immune cells via FcgammaR, and the development of FcgammaR-mediated autoimmune diseases
the importance of MALT1-mediated inflammation and T cell activation to control ERA virus, providing new insights in the biology of MALT1 and rabies virus infection.
MALT1 as a key molecule that contributes to immune tolerance at steady-state while facilitating immune reactivity under stress conditions.
Data show that inhibition of the protease activity of MALT1 might be a strategy to treat inflammatory bowel disease and the NLRP3 (Montrer NLRP3 Protéines) inflammasome and NF-kappaB (Montrer NFKB1 Protéines) activation are critical components in MALT1 signaling cascades in this disease model.
MALT1 function is required in B cells for germinal center formation.
Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE)
Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review)
TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
mucosa associated lymphoid tissue lymphoma translocation gene 1
, mucosa associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1-like
, MALT associated translocation
, MALT lymphoma-associated translocation
, MALT-lymphoma associated translocation
, caspase-like protein
, mucosa-associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog