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Human Monoclonal POLD3 Primary Antibody pour IF, ELISA - ABIN564666
Bursomanno, Beli, Khan, Minocherhomji, Wagner, Bekker-Jensen, Mailand, Choudhary, Hickson, Liu: Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells. dans DNA repair 2014
The proofreading activity of DNA polymerase delta (Montrer POLD1 Anticorps) plays a role in shunting DNA mismatch repair to an EXO1 (Montrer EXO1 Anticorps)-dependent excision pathway as opposed to directly participating in gap formation via its 3'-5' exonuclease (Montrer EXOSC10 Anticorps) activity.
The mitotic DNA synthesis is RAD52 (Montrer RAD52 Anticorps) dependent, and RAD52 (Montrer RAD52 Anticorps) is required for the timely recruitment of MUS81 (Montrer MUS81 Anticorps) and POLD3 to common fragile sites in early mitosis.
Studies indicate that DNA polymerase delta 3 (Pol delta3) exhibits significant differences in properties with a major impact on cellular processes in genomic surveillance, DNA replication and DNA repair.
Data suggest that relatively high affinity binding of PolD3-RIR (Montrer APBB1 Anticorps) motif to Rev1 (Montrer REV1 Anticorps)-C-terminal domain displaces subunits from PolN, Pol-iota (Montrer POLM Anticorps), or PolK (Montrer PAPD7 Anticorps) from Rev1 (Montrer REV1 Anticorps) complex and promotes formation of Rev1 (Montrer REV1 Anticorps)/PolZ4 assembly with PCNA (Montrer PCNA Anticorps) for translesion DNA replication.
POLD3 is SUMOylated by SUMO2 (Montrer SUMO2 Anticorps) in response to replication stress and could play an important role in the regulation of cellular response to DNA replication stress.
Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells.
In a cyclin E (Montrer CCNE1 Anticorps) overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis.
Pol delta3 is the predominant form of Pol delta (Montrer POLD1 Anticorps) at sites of UV damage as a result of p12 (Montrer POLE4 Anticorps) degradation; results show that Pol delta (Montrer POLD1 Anticorps) at the DNA damage site is the Pol delta (Montrer POLD1 Anticorps) trimer lacking p12 (Montrer POLE4 Anticorps) regardless of the cell cycle phase
We identified three new CRC (Montrer CALR Anticorps) risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2 (Montrer SHROOM2 Anticorps); P = 7.30 x 10(-10)).
Serine-458, located in the proliferating cell nuclear antigen (PCNA (Montrer PCNA Anticorps))-interacting motif of Poldelta(p68 (Montrer ANXA6 Anticorps)), is a phosphorylation site for protein kinase A (PKA); p68 (Montrer ANXA6 Anticorps) mutation results in decreased p68 (Montrer ANXA6 Anticorps) affinity for PCNA (Montrer PCNA Anticorps) as well as processivity of Poldelta.
POLD3 deficiency is lethal in mice, Pold3 heterozygous mice are born at sub-Mendelian ratios.
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene.
DNA-directed DNA polymerase delta 3
, DNA polymerase delta p66 subunit
, DNA polymerase delta subunit 3
, polymerase (DNA-directed), delta 3, accessory subunit
, DNA polymerase delta subunit 3-like
, DNA polymerase delta subunit p66
, Pol delta C subunit (p66)
, polymerase (DNA directed), delta 3