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anti-Human NDFIP1 Anticorps:
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Monoclonal NDFIP1 Primary Antibody pour ELISA, WB - ABIN534181
Oliver, Cao, Worthen, Shi, Briones, MacLeod, White, Kirby, Kappler, Marrack, Yang: Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. dans Immunity 2006
we identified Nedd4-family interacting protein 1 as a direct target of miR-155, and the expression of Nedd4-family interacting protein 1 was inhibited by miR-155. Furthermore, ectopic expression of Nedd4-family interacting protein 1 restored the effects of miR-155 on cell proliferation and invasion of uveal melanoma cells
the expression of Ndfipl reduced expression of a-synuclein. In conclusion, Ndfipl plays a significant role in protecting SH-SY5Y cells in in vitro Parkinson's disease models.
Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin secretion. These effects were associated with an increase in the cellular content of JunB, a potent inhibitor of ER stress and apoptosis.
Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.
Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 into the nucleus.
In Parkinson's disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1, including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes.
Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation.
Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes.
PTEN/Akt and MAP kinase signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 and Ndfip2
Ndfip1 is required for the exosomal secretion of Nedd4 family proteins
Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them.
Ndfip1 plays a critical role in regulating metal transport in human neurons through its regulation of DMT1.
Ndfip1 preserves Treg lineage stability and immune homeostasis by preventing the expansion of highly proliferative and metabolically active Treg cells and by preventing pathological secretion of IL-4 from Treg cells
Data support an essential role for Ndfip1 in degrading RORgammaT and suppressing Th17 lineage stability, proinflammatory cytokine production, and pathogenicity.
Findings indicate an important negative regulatory function for Nedd4 ubiquitin protein ligase (Nedd4-2) and Nedd4 family interacting protein 1 (Ndfip1) in IgE-dependent mast cell activity.
Data indicate thar Janus kinase 1 (Jak1) degradation is dependent on Nedd4 family interacting proteins Ndfip1/Ndfip2.
transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors, resulting in microencephaly.
It attenuates 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.
The results of this study indicated that Ndfip1, through its Nedd4 effectors, is important for the development of dendrites and dendritic spines in the cortex
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
Genomic deletion of Ndfip1 abrogated nuclear trafficking of ubiquitinated Pten, even in the presence of Rab5.
Iron status and lipopolysaccharide regulate Ndfip1 by activation of nuclear factor-kappa B.
Ndfip1 deficiency precipitated autoimmune pancreatic destruction and diabetes; however, this depended on a further accumulation of nontolerant anti-self T cells from strong stimulation by exogenous tolerogen
Factors that induce IL-2 expression downstream of TCR engagement also induce the expression of Ndfip1 to limit the extent of IL-2 production and dampen T cell activation.
dynamic pattern of Ndfip1 expression in temporal and spatial domains of the cortical landscape is indicative of complex programs of protein ubiquitination during corticogenesis.
Ndfip1 is a molecular regulator of the exosomal export of PTEN.
Mice lacking Ndfip1, an adaptor protein for E3 ubiquitin ligases of the Nedd4-family, in T cells (Ndfip1-cKO) develop a disease resembling IBD.
Ndfip1 acts to prevent Th17 differentiation, much like it does for Th2 differentiation.
we propose that TGF-beta signaling induces Ndfip1 expression to silence IL-4 production, thus permitting iT(reg) cell differentiation.
regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins.
Nedd4 WW binding protein 5
, Nedd4 family interacting protein 1
, Nedd4 WW domain-binding protein 5
, NEDD4 family-interacting protein 1
, breast cancer-associated protein SGA-1M
, putative MAPK-activating protein PM13
, putative NF-kappa-B-activating protein 164
, putative NFKB and MAPK-activating protein
, NEDD4 WW domain-binding protein 5
, Nedd4 WW-binding protein 5