CDC42 anticorps (AA 1-191)
(3 références)Aperçu rapide pour CDC42 anticorps (AA 1-191) (ABIN968255)
Antigène
Voir toutes CDC42 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 1-191
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Réactivité croisée
- Rat (Rattus), Chien, Souris
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Human CDC42 aa. 1-191
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Isotype
- IgG1
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anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) (AA 25-191) antibody
CDC42 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) (AA 16-188) antibodyCDC42 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, FACS Hôte: Lapin Polyclonal unconjugated
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) antibodyKD Validated CDC42 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 23GB740 unconjugated Recombinant Antibody
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) antibodyKD Validated CDC42 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 23GB1025 unconjugated Recombinant Antibody
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) (AA 1-191) antibodyCDC42 Reactivité: Humain, Souris, Rat, Chien WB, IF Hôte: Souris Monoclonal 44-CDC42 unconjugated
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) antibodyCDC42 Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Monoclonal 3C3 unconjugated Recombinant Antibody
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) (AA 1-191) antibodyCDC42 Reactivité: Humain WB, PLA Hôte: Lapin Polyclonal unconjugated
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) (AA 121-138), (Middle Region) antibodyCDC42 Reactivité: Humain, Souris, Rat, Boeuf (Vache) WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) antibodyCDC42 Reactivité: Humain, Souris, Rat IHC Hôte: Lapin Polyclonal unconjugated
anti-Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) (AA 1-188) antibodyCDC42 Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
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Commentaires
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Related Products: ABIN967389, ABIN968545
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20°C.
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: "Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation." dans: Genes & development, Vol. 17, Issue 2, pp. 295-309, (2003) (PubMed).
: "Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway." dans: The Journal of biological chemistry, Vol. 277, Issue 23, pp. 20903-10, (2002) (PubMed).
: "Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt." dans: Molecular and cellular biology, Vol. 21, Issue 19, pp. 6706-17, (2001) (PubMed).
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- CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))
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Autre désignation
- Cdc42
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Sujet
- Rho family members are small GTP binding proteins that serve as molecular switches for a number of biological processes. They cycle between active GTP-bound and inactive GDP-bound states. CDC42 is a Rho family protein that was identified in membranes of human platelets and placenta. It is the homologue of CDC42Sc, which regulates initiation of bud-site assembly in Saccharomyces cerevisiae. CDC42 regulates the function of the mammalian actin cytoskeleton, allowing for efficient cytokinesis and cell morphogenesis. CDC42 and Rac1, a Ras-related GTPase, activate MEKK1, a JNK kinase kinase, which leads to the activation of several downstream components of the MAP kinase cascade leading to activation of PAK65, a CDC42- and Rac-binding protein. PAK65 interacts with CDC42/Rac1, mediates their interaction with MEKK1, and enhances MEKK1 catalytic activity. Chronic activation of CDC42 has been shown to induce malignant cellular transformation. Due to sequence homology among various small GTPase family members, potential cross-reactivity could be observed with this antibody.
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Poids moléculaire
- 22 kDa
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Pathways
- Signalisation MAPK, Dynamique des Microtubules, Signalisation RTK, Signalisation WNT, TCR Signaling, EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2, EGFR Downregulation, VEGF Signaling
Antigène
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