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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. De plus, nous expédions ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Protéines (11) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal ABCB1B Primary Antibody pour FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. dans Journal of experimental & clinical cancer research : CR 2009
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Compared with the sensitive group, both mdr1 (Montrer TBC1D9 Anticorps) mRNA and P-gp (Montrer ABCB4 Anticorps) expressions increased in the resistant group
an SNP in ABCB1 (Montrer ABCB1 Anticorps) (rs2032582: 2677G > T/A) was significantly associated with atorvastatin-induced liver injury (AILI) indicating that the G allele might be a risk factor for AILI in Japanese population
impact of CYP4F2 (Montrer CYP4F2 Anticorps), ABCB1 (Montrer ABCB1 Anticorps), and GGCX (Montrer GGCX Anticorps) polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation
Collectively, the data establish a hitherto unknown liaison among MDR1 (Montrer TBC1D9 Anticorps), BMI1 (Montrer BMI1 Anticorps) and TIP60 (Montrer KAT5 Anticorps) and provide mechanistic insights into cisplatin-induced MDR1 (Montrer TBC1D9 Anticorps) expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.
High ABCB1 (Montrer ABCB1 Anticorps) expression is associated with hepatocellular carcinoma.
Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 (Montrer TBC1D9 Anticorps) gene are associated with Crohn's disease and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.
ATPase (Montrer DNAH8 Anticorps) measurements imply that DCV and Ho are similarly handled by ABCB1 (Montrer ABCB1 Anticorps), whereas ABCG2 (Montrer ABCG2 Anticorps) seems to transport DVC more effectively. In addition, we have developed an image-based high content microscopy screening method for simultaneous in situ measurement of the cellular activity and expression of the ABCG2 (Montrer ABCG2 Anticorps) multidrug transporter
These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 (Montrer ABCC1 Anticorps) in recipient cells is governed by the transfer of both miR (Montrer MLXIP Anticorps)-326 and ABCB1 (Montrer ABCB1 Anticorps) from donor cells
he modulatory effect of acacetin-doxorubicin combination on doxorubicin influx and efflux was mediated through downregulation of MDR1 (Montrer TBC1D9 Anticorps) treansporter in non-small-cell lung carcinoma (NSCLC) cells.
An additional action of osimertinib that directly inhibits the function of ABCB1 (Montrer ABCB1 Anticorps).
Loss of ABCB1 (Montrer ABCB1 Anticorps) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (Montrer ABCB4 Anticorps) ATPase (Montrer DNAH8 Anticorps) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (Montrer ABCB4 Anticorps) activity and reverse the up-regulated P-gp (Montrer ABCB4 Anticorps) and MDR1 (Montrer ABCB4 Anticorps) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (Montrer ABCB4 Anticorps) gene expression and activity in an enantiomer-specific way.
Pgp (Montrer ABCB4 Anticorps)-coupled ATPase (Montrer DNAH8 Anticorps) activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.
Data show that human transgenic mutant huntingtin (Montrer HTT Anticorps) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (Montrer ABCB4 Anticorps)) which suggests that MDR1 (Montrer ABCB4 Anticorps) might be a potential therapeutic target for Huntington's disease.
In vitro and in vivo downregulation of the ATP binding cassette transporter (Montrer ABCC3 Anticorps) B1 by the HMG-CoA reductase (Montrer HMGCR Anticorps) inhibitor simvastatin
Efficient chemoprotection of CDD (Montrer CDA Anticorps) and MDR1 (Montrer ABCB4 Anticorps) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (Montrer FOXC1 Anticorps)-C and anthracycline application
These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (Montrer ABCB1 Anticorps)-1Delta mutant mice following exposure to various P-gp (Montrer ABCB4 Anticorps) substrates.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1