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MAP4K5 encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. De plus, nous expédions Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 Protéines (12) et beaucoup plus de produits pour cette protéine.
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MAP4K5 expression is decreased or lost in majority of pancreatic ductal adenocarcinoma.
TNF (Montrer TNF Anticorps) signaling leads to oligomerization, ubiquitination, and activation of GCKR (Montrer GCKR Anticorps) and activation of the SAPK (Montrer MAPK9 Anticorps) pathway in a manner that depends upon TRAF2 (Montrer TRAF2 Anticorps) polyubiquitination and oligomerization and Ubc13 (Montrer UBE2N Anticorps) function
The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Han Chinese from Shanghai.
Germinal center kinase-related enzyme (GCKR (Montrer GCKR Anticorps)) facilitates both canonical and noncanonical Wnt (Montrer WNT2 Anticorps) signaling in B lymphocytes.
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
MAPK/ERK kinase kinase kinase 5
, MEK kinase kinase 5
, MEKKK 5
, germinal center kinase-related
, kinase homologous to SPS1/STE20