anti-Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Anticorps

Exhibits an oxidoreductive catalytic activity towards retinoids. De plus, nous expédions RDH12 Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
RDH12 77974 Q8BYK4
RDH12 145226 Q96NR8
RDH12 314264  
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Top anti-RDH12 Anticorps sur anticorps-enligne.fr

Showing 10 out of 22 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Chien Lapin Inconjugué WB <b>WB Suggested Anti-RDH12 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Transfected 293T 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB <b>WB Suggested Anti-RDH12 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Human Intestine 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
$551.83
Détails
Boeuf (Vache) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, WB 50 μg Connectez-vous pour afficher 2 to 3 Days
$433.13
Détails
Humain Souris Inconjugué IF, ELISA, WB Detection limit for recombinant GST tagged RDH12 is 0.3 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to RDH12 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Connectez-vous pour afficher 11 to 12 Days
$430.00
Détails
Humain Lapin Inconjugué WB Western Blot: RDH12 Antibody [NBP1-57955] - Transfected 293T cell lysate, concentration 0.2-1 ug/ml. 100 μL Connectez-vous pour afficher 8 to 11 Days
$447.56
Détails
Humain Lapin Inconjugué WB Western Blot analysis of RDH12 expression in transfected 293T cell line by RDH12 MaxPab polyclonal antibody.<br><br>Lane 1: RDH12 transfected lysate(35.10 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Connectez-vous pour afficher 11 to 12 Days
$418.57
Détails
Humain Souris Inconjugué WB Western Blot analysis of RDH12 expression in transfected 293T cell line by RDH12 MaxPab polyclonal antibody.<br><br>Lane 1: RDH12 transfected lysate(34.76 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Connectez-vous pour afficher 11 to 12 Days
$430.00
Détails
Humain Lapin Inconjugué ELISA, WB   150 μL Connectez-vous pour afficher 13 to 16 Days
$753.50
Détails

RDH12 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité
Mouse (Murine)


Human
,
,
Rat (Rattus)


anti-RDH12 Anticorps mieux référencés

  1. Dog (Canine) Polyclonal RDH12 Primary Antibody pour WB - ABIN2785175 : Sun, Gerth, Maeda, Lodowski, Van Der Kraak, Saperstein, Héon, Palczewski: Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. dans Vision research 2007 (PubMed)

Plus d’anticorps contre RDH12 partenaires d’interaction

Mouse (Murine) Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) interaction partners

  1. RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell.

  2. RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye.

  3. The present findings, together with those of earlier studies showing only minor functional deficits in mice deficient for Rdh5 (Montrer RDH5 Anticorps), Rdh8 (Montrer HSD17B6 Anticorps), or Rdh11 (Montrer RDH11 Anticorps), suggest that the activity of any one isoform is not rate limiting in the visual response.

  4. Oxidative stress induced (Montrer SQSTM1 Anticorps) by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 (Montrer RDH11 Anticorps) suggested a housekeeping function for this enzyme.

  5. a critical function of RDH12 is the reduction of all-trans-retinal that exceeds the reductive capacity of the photoreceptor outer segments

Human Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) interaction partners

  1. Peripapillary sparing is a novel phenotypic feature of RDH12-associated Leber congenital amaurosis.

  2. The mutation detection of RDH12 in this study also implies that whole exome sequencing is a useful method for detection of potential mutations in small families with atypical clinical manifestations of genetic disease.

  3. We report 4 children from 3 consanguineous families with bilateral elevation deficiency in the context of retinal dystrophy (Montrer MERTK Anticorps). All were found to harbor recessive mutations in retinal dehydrogenase 12 (RDH12).

  4. Mutations in the AIPL1 (Montrer AIPL1 Anticorps) and RDH12 genes associated with leber congenital amaurosis in two Turkish families.

  5. Here we demonstrate that microtubule-associated protein 1 light chain 3A (Montrer MAP1LC3A Anticorps) (LC3A (Montrer MAP1LC3A Anticorps)), a marker of autophagy, is related to hypoxia and poor prognosis in clear cell ovarian cancer.

  6. The three patients with Leber congenital amaurosis/early-onset retinal dystrophy (Montrer MERTK Anticorps) had a progressive decrease of their vision with the formation of a posterior staphyloma.

  7. Two novel missense mutations in the RDH12 gene are associated with retinitis pigmentosa.

  8. Seventeen novel mutations in the RDH12 gene were identified that accounted for approximately 7% of disease in a cohort of patients diagnosed with Leber congenital amaurosis and early-onset retinal dystrophy (Montrer MERTK Anticorps).

  9. LCA (Montrer CLTA Anticorps) has been associated with sequence variations of 14 different genes; in approximately 30% of all cases pathogenic mutations remain to be determined.

  10. The retina RDH12 reduces 4-HNE (Montrer ELANE Anticorps) to a nontoxic alcohol, protecting cellular macromolecules against oxidative modification and protecting photoreceptors from light-induced apoptosis.

RDH12 profil antigène

Profil protéine

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity).

Gene names and symbols associated with RDH12

  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (RDH12) anticorps
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (rdh12) anticorps
  • retinol dehydrogenase 12 (MAV_1968) anticorps
  • retinol dehydrogenase 12 (CC1G_02720) anticorps
  • Retinol dehydrogenase 12 (Bm1_36660) anticorps
  • retinol dehydrogenase 12 (PTRG_03574) anticorps
  • retinol dehydrogenase 12 (PTRG_05326) anticorps
  • retinol dehydrogenase 12 (PTRG_08067) anticorps
  • retinol dehydrogenase 12 (LOC100282710) anticorps
  • retinol dehydrogenase 12 (LOC100285880) anticorps
  • retinol dehydrogenase 12 (LOC100226769) anticorps
  • retinol dehydrogenase 12 (Rdh12) anticorps
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (Rdh12) anticorps
  • A930033N07Rik anticorps
  • DSSDR2 anticorps
  • LCA3 anticorps
  • LCA13 anticorps
  • RP53 anticorps
  • SDR7C2 anticorps
  • wu:fj43a10 anticorps
  • zgc:92430 anticorps

Protein level used designations for RDH12

retinol dehydrogenase 12 (all-trans and 9-cis) , retinol dehydrogenase 12 , Retinol dehydrogenase 12 , retinol dehydrogenase 12 (all-trans/9-cis/11-cis) , all-trans and 9-cis retinol dehydrogenase , retinol dehydrogenase 12, all-trans and 9-cis , short chain dehydrogenase/reductase family 7C, member 2 , double substrate specificity short chain dehydrogenase/reductase 2 , double substrate specificity short-chain dehydrogenase/reductase 2 , double substrate-specificity short chain dehydrogenase/reductase 2

GENE ID SPECIES
423274 Gallus gallus
436597 Danio rerio
4528332 Mycobacterium avium 104
6016890 Coprinopsis cinerea okayama7130
6102217 Brugia malayi
6341805 Pyrenophora tritici-repentis Pt-1C-BFP
6343577 Pyrenophora tritici-repentis Pt-1C-BFP
6346345 Pyrenophora tritici-repentis Pt-1C-BFP
100282710 Zea mays
100285880 Zea mays
490744 Canis lupus familiaris
711438 Macaca mulatta
100226769 Taeniopygia guttata
77974 Mus musculus
145226 Homo sapiens
314264 Rattus norvegicus
369021 Bos taurus
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