anti-Sclerostin (SOST) Anticorps

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. De plus, nous expédions Sclerostin Kits (57) et Sclerostin Protéines (18) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top anti-Sclerostin Anticorps sur anticorps-enligne.fr

Showing 10 out of 128 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-SOST Antibody (N-term) Pab (ABIN390193) in mouse liver tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SOST antibody (N-term)(ABIN390193), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of SOST Antibody (Center) (ABIN390194) in mouse lung tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody (Center)(ABIN390194), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated (ABIN1714867) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse lung probed with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated  at 1:5000 for 90 min at 37˚C. 100 μL Connectez-vous pour afficher 18 to 22 Days
304,36 €
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of HeLa and HepG2 cell lines, using SOST antibody. Immunohistochemistry of paraffin-embedded human prostate using SOST antibody at dilution of 1:100 (40x lens). 100 μL Connectez-vous pour afficher 12 Days
261,90 €
Détails
Humain Lapin Inconjugué WB SOST Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SOST antibody detected the SOST protein (arrow). 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Souris Chèvre Inconjugué IHC, WB 100 μg Connectez-vous pour afficher 11 to 14 Days
967,30 €
Détails
Humain Lapin Alexa Fluor 594 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails

SOST Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Sclerostin Anticorps mieux référencés

  1. Human Polyclonal Sclerostin Primary Antibody pour IHC (p), WB - ABIN390193 : Semenov, He: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. dans The Journal of biological chemistry 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal Sclerostin Primary Antibody pour EIA, IHC (p) - ABIN358751 : Ellies, Viviano, McCarthy, Rey, Itasaki, Saunders, Krumlauf: Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. dans Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre Sclerostin partenaires d’interaction

Human Sclerostin (SOST) interaction partners

  1. observed an association between sclerostin levels with fasting insulin (Montrer INS Anticorps) levels and homoeostatic model assessment-insulin (Montrer INS Anticorps) resistance, but there was no clear association with type 2 diabetes risk.

  2. Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR (Montrer EGFR Anticorps). Its involvement with other hormones of mineral homeostasis (FGF23 (Montrer FGF23 Anticorps)/Klotho (Montrer KL Anticorps) and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney

  3. In chronic kidney disease, serum levels of the Wnt (Montrer WNT2 Anticorps) inhibitors DKK1 (Montrer DKK1 Anticorps) and sclerostin are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin, as opposed to DKK1 (Montrer DKK1 Anticorps), may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD (Montrer DPEP1 Anticorps)), particularly in dialysis patients.

  4. Vitamin D receptor (Montrer VDR Anticorps) agonism by paricalcitol causes a moderate increase in serum sclerostin in CKD patients, and this effect is modified by circulating pentosidine levels.

  5. SOST is frequently expressed in skeletal bone- and cartilage-forming tumors. The strong spatial correlation with bone formation and the in vitro expression patterns are in line with the known functions of SOST in nonneoplastic bone, as a feedback inhibitor on osteogenic differentiation.

  6. Intermittent compressive stress regulates Notch (Montrer NOTCH1 Anticorps) receptor and target gene expression via the TGF-beta (Montrer TGFB1 Anticorps) signaling pathway. Notch (Montrer NOTCH1 Anticorps) signaling participates in TGF-beta (Montrer TGFB1 Anticorps)-induced sclerostin expression in periodontal ligament cells.

  7. Dickkopf-1 (Montrer DKK1 Anticorps) and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone. Sclerostin was positively correlated with age.

  8. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  9. Circulating sclerostin and Dickkopf-1 (Montrer DKK1 Anticorps) levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women.

  10. SOST is expressed in the aorta and downregulated in human aortic aneurysms and atheros (Montrer WNT2 Anticorps)clerosis, possibly because of epigenetic silencing.

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  2. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  3. Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (Montrer WNT2 Anticorps) signaling pathway inhibition.

  4. Analysis of SOST expression using large minigenes reveals the MEF2C (Montrer MEF2C Anticorps) binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFbeta1 (Montrer TGFB1 Anticorps) responsiveness.

  5. removal of sclerostin appears to modestly protect the alveolar bone from resorption in this experimental setting

  6. chronic TNFalpha (tumor necrosis factor alpha (Montrer TNF Anticorps))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

  7. Data show that the phenotype of Notch (Montrer NOTCH1 Anticorps) activation in osteocytes was prevented in matrix protein 1 (Dmp1 (Montrer DMP1 Anticorps))-Cre;Rosa(Notch (Montrer NOTCH1 Anticorps)) mice hemizygous for the Dmp1 (Montrer DMP1 Anticorps)-sclerostin (SOST) transgene.

  8. Results found that sclerostin enhances adipocyte differentiation in 3T3-L1 cells and reduced TAZ (Montrer TAZ Anticorps)-responsive transcriptional activity and TAZ (Montrer TAZ Anticorps)-responsive gene expression, indicating a role for TAZ (Montrer TAZ Anticorps) as a regulator of adipogenesis by sclerostin.

  9. Our results suggested that sclerostin could be expressed in the liver and sustained successfully at high levels in the blood by using the PhiC31 integrase system, leading to trabecular bone loss.

  10. Sclerostin depletion enhances tibial fracture healing.

Sclerostin (SOST) profil antigène

Profil protéine

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with anti-Sclerostin (SOST) Anticorps

  • sclerostin (LOC100313724) anticorps
  • sclerostin (SOST) anticorps
  • sclerostin (Sost) anticorps
  • sclerostin-like (LOC100513306) anticorps
  • 5430411E23Rik anticorps
  • CDD anticorps
  • LOC100313724 anticorps
  • VBCH anticorps

Protein level used designations for anti-Sclerostin (SOST) Anticorps

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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