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anti-Sphingosine Kinase 1 (SPHK1) Anticorps

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. De plus, nous expédions Sphingosine Kinase 1 Protéines (13) et Sphingosine Kinase 1 Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
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Top anti-Sphingosine Kinase 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 201 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Chèvre Inconjugué ELISA, WB ABIN308402 (2µg/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue (hepatocarcinoma) reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. The anti-SPHK1 Pab is used in Western blot to detect SPHK1 in mouse kidney tissue lysate. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué EIA, WB The anti-SphK1 Pab is used in Western blot (Lane 2) to detect c-myc-tagged SphK1 in transfected 293 cell lysate (a c-myc antibody is used as control in Lane 1). Data is kindly provided by Dr. J. Van Brocklyn from the Ohio State University (Columbus, OH). Western blot analysis of anti-hSPHK1-M1 Pab in 293 cell line lysates transiently transfected with the SPHK1 gene (2 µg/lane). hSPHK1-M1(arrow) was detected using the purified Pab (1:60 dilution). 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Lapin Inconjugué WB The anti-SphK1 Pab (ABIN391345) is used in Western blot (Lane 2) to detect c-myc-tagged SphK1 in transfected 293 cell lysate (a c-myc antibody is used as control in Lane 1). Data is kindly provided by Dr. J. Van Brocklyn from the Ohio State University (Columbus, OH). Western blot analysis of anti-hSPHK1-M1 Pab (ABIN391345) in 293 cell line lysates transiently transfected with the SPHK1 gene (2 µg/lane). hSPHK1-M1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué IHC (p), WB The anti-SPHK1 Pab (ABIN391346) is used in Western blot to detect SPHK1 in mouse kidney tissue lysate. Western blot analysis of anti-SPHK1 Antibody (Center) (ABIN391346) in 293 cell line lysates (35 µg/lane). SPHK1 (arrow) was detected using the purified polyclonal antibody. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of anti-SPHK1 Antibody (N-term) in K562 cell line lysates (35 µg/lane). SPHK1 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Humain Chèvre Inconjugué EIA, WB 20 μg Connectez-vous pour afficher 8 to 10 Days
220,00 €
Détails
Boeuf (Vache) Chèvre Inconjugué EIA, IP, WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: Sphingosine Kinase 1/SPHK1 Antibody [NBP1-02310] - (2ug/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Souris Lapin Inconjugué WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
594,00 €
Détails

SPHK1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Sphingosine Kinase 1 Anticorps mieux référencés

  1. Human Polyclonal SPHK1 Primary Antibody pour IHC (p), WB - ABIN391346 : Nayak, Huo, Kwang, Pushparaj, Kumar, Ling, Dheen: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. dans Neuroscience 2010 (PubMed)
    Show all 17 references for ABIN391346

  2. Human Polyclonal SPHK1 Primary Antibody pour EIA, WB - ABIN359437 : Nava, Lacana, Poulton, Liu, Sugiura, Kono, Milstien, Kohama, Spiegel: Functional characterization of human sphingosine kinase-1. dans FEBS letters 2000 (PubMed)
    Show all 5 references for ABIN359437

  3. Human Polyclonal SPHK1 Primary Antibody pour EIA, IHC (p) - ABIN359438 : Li, Yu, Xia, Zhang, Weng, Zheng, Kong, Hu, Zeng, Zeng, Li, Li, Song: Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2009 (PubMed)
    Show all 5 references for ABIN359438

  4. Human Polyclonal SPHK1 Primary Antibody pour EIA, WB - ABIN359439 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... dans Nature genetics 2003 (PubMed)
    Show all 4 references for ABIN359439

  5. Human Polyclonal SPHK1 Primary Antibody pour ELISA, WB - ABIN314839 : Igarashi, Okada, Hayashi, Fujita, Jahangeer, Nakamura: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. dans The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN314839

  6. Human Polyclonal SPHK1 Primary Antibody pour WB - ABIN391345 : Hayashi, Nakagami, Takami, Koriyama, Mori, Tamai, Sun, Nagao, Morishita, Kaneda: FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. dans Arteriosclerosis, thrombosis, and vascular biology 2009 (PubMed)
    Show all 2 references for ABIN391345

  7. Mouse (Murine) Polyclonal SPHK1 Primary Antibody pour WB - ABIN4620349 : Kihara, Ikeda, Kariya, Lee, Lee, Igarashi: Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. dans The Journal of biological chemistry 2003 (PubMed)

  8. Human Polyclonal SPHK1 Primary Antibody pour EIA, WB - ABIN782886 : Kohama, Olivera, Edsall, Nagiec, Dickson, Spiegel: Molecular cloning and functional characterization of murine sphingosine kinase. dans The Journal of biological chemistry 1998 (PubMed)

  9. Human Polyclonal SPHK1 Primary Antibody pour ELISA, WB - ABIN308402 : Kase, Hattori, Jojima, Okayasu, Tomizawa, Suzuki, Banba, Monden, Satoh, Akimoto, Kasai: Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells. dans Life sciences 2007 (PubMed)

Plus d’anticorps contre Sphingosine Kinase 1 partenaires d’interaction

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sk1 and Sk2 (Montrer KCNN2 Anticorps) are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK/phyto-S1P (Montrer MBTPS1 Anticorps) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

  1. demonstrated the roles played by miR (Montrer MLXIP Anticorps)-144-3p and FN1 (Montrer FN1 Anticorps) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (Montrer F9 Anticorps)

  2. SphK1 is associated with the proliferation and invasiveness of CRC (Montrer CALR Anticorps) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (Montrer CALR Anticorps).

  3. The levels of SphK1 were significantly increased in triple-negative breast cancer patients compared with normal controls. SphK1 knockdown with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion, suggesting that SphK1 has an important role in TNBC.

  4. SPHK1 mRNA is up-regulation in colorectal cancer.

  5. Found that upregulation of SphK1 expression in the stiff substrate is dominant in metastatic cancer cells but not in primary cancer cells. These results suggest that alterations in the mechanical environment of the extracellular matrix surrounding the tumor cells actively regulate cellular properties such as secretion, which in turn, may contribute to cancer progression.

  6. In conclusion, these data suggested that HuR (Montrer ELAVL1 Anticorps) bound to SphK1 mRNA and played a crucial role in TGF-beta1 (Montrer TGFB1 Anticorps)-induced hepatic stellate cell activation.

  7. low oxLDL concentration triggers sprouting angiogenesis that involves ROS (Montrer ROS1 Anticorps)-induced activation of the neutral sphingomyelinase-2 (Montrer SMPD3 Anticorps)/sphingosine kinase-1 pathway, and is effectively inhibited by GW4869.

  8. SphK1 expression is functionally associated to cellular proliferation, apoptosis, invasion and mitotane sensitivity of adrenocortical carcinoma.

  9. Data show that long non-coding RNA HULC promotes tumor angiogenesis in liver cancer through microRNA miR (Montrer MLXIP Anticorps)-107/E2F1 transcription factor (E2F1 (Montrer E2F1 Anticorps))/sphingosine kinase 1 (SPHK1) signaling.

  10. High SPHK1 expression is associated with ovarian cancer.

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (Montrer AGER Anticorps)/SphK1 signaling pathway in db/db (Montrer LEPR Anticorps) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.

  2. Keratinocyte-specific deletion of Traf2 (Montrer TRAF2 Anticorps), but not Sphk1 deficiency, disrupted TNF (Montrer TNF Anticorps) mediated NF-kappaB (Montrer NFKB1 Anticorps) and MAP kinase (Montrer MAPK1 Anticorps) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.

  3. SphK1 dependent PKC-delta (Montrer PKCd Anticorps) activation plays an important role in promoting NF-kappaB (Montrer NFKB1 Anticorps) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (Montrer PKCd Anticorps) activation might be a potential therapeutic strategy for this disease.

  4. Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (Montrer HMGB1 Anticorps) cytoplasmic translocation in liver cells.

  5. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (Montrer SCRIB Anticorps) activity in vitro and in vivo.

  6. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

  7. Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.

  8. Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (Montrer MC4R Anticorps)-SphK1 signaling.

  9. The study demonstrates a new pathway connecting SphK1 and PPARgamma (Montrer PPARG Anticorps) involved in the pathogenesis of hepatocellular steatosis.

  10. Inhibition of SK1 attenuates the second phase of transmembrane Calcium influx.

Sphingosine Kinase 1 (SPHK1) profil antigène

Profil protéine

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPHK1

  • Sphingosine kinase 1 (Sk1) anticorps
  • sphingosine kinase 1 (SPHK1) anticorps
  • sphingosine kinase 1 (sphk1) anticorps
  • sphingosine kinase 1 (LOC100357790) anticorps
  • sphingosine kinase 1 (Sphk1) anticorps
  • 1110006G24Rik anticorps
  • CG1747 anticorps
  • Dmel\\CG1747 anticorps
  • F18E5.160 anticorps
  • F18E5_160 anticorps
  • Sk1 anticorps
  • sphingosine kinase 1 anticorps
  • SPHK anticorps
  • SPHK1 anticorps
  • Spk1 anticorps

Protein level used designations for SPHK1

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPECIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
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