Activin A Receptor, Type IIB (ACVR2B) anticorps (HRP)

Détails pour le produit réf. ABIN1712165, Fournisseur: Connectez-vous pour afficher
Antigène
  • ACVR2B
  • XAR1
  • actr-iib
  • actriib
  • ACTRIIB
  • ActR-IIB
  • HTX4
  • ActRIIB
  • actr2b
  • actrIIb
  • wu:fj97d11
  • activin A receptor, type IIB
  • activin receptor IIb
  • activin receptor IIB
  • ACVR2B
  • acvr2b
  • Acvr2b
Reactivité
Humain, Souris, Rat (Rattus)
120
57
31
9
7
6
6
6
5
4
3
3
3
2
2
2
1
Hôte
Lapin
103
29
5
Clonalité
Polyclonal
Conjugué
HRP
12
8
5
4
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
111
54
49
24
13
6
3
2
2
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human ACVR2B/ACTR-IIB
Isotype IgG
Purification Purified by Protein A.
Autre désignation Acvr2b/Actr-Iib (ACVR2B Antibody Extrait)
Sujet

Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.

Subcellular location: Extracellular

Synonyms: HTX4, ACTRIIB, ActR-IIB, Activin receptor type-2B, Activin receptor type IIB, ACVR2B

ID gène 93
UniProt Q13705
Pathways Hormone Transport
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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