FLIP anticorps (C-Term)
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- Antigène Voir toutes FLIP (CFLAR) Anticorps
- FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
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Épitope
- AA 191-209, C-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FLIP est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- This antibody recognises the apoptosis related protein designated FLIP (FLICE inhibitory protein).
- Purification
- Purified
- Immunogène
- A peptide corresponding to aa191 - 209 at the C-terminus of human FLIP delta/FLIPs form.
- Isotype
- IgG
- Top Product
- Discover our top product CFLAR Anticorps primaire
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- Indications d'application
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Immunohistochemistry on frozen sections: 2g/mL. Western Blot: 1: 1000, detects bands of approximately 35 kDa and 25 kDa in Jurkat celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
- Autre désignation
- CFLAR / Casper / I-FLICE (CFLAR Produits)
- Synonymes
- anticorps Clarp1, anticorps cflar, anticorps CFLAR, anticorps FLIP, anticorps CASH, anticorps CASP8AP1, anticorps CLARP, anticorps Casper, anticorps FLAME, anticorps FLAME-1, anticorps FLAME1, anticorps I-FLICE, anticorps MRIT, anticorps c-FLIP, anticorps c-FLIPL, anticorps c-FLIPR, anticorps c-FLIPS, anticorps 2310024N18Rik, anticorps A430105C05Rik, anticorps Cash, anticorps ENSMUSG00000072980, anticorps Flip, anticorps Gm9845, anticorps c-Flip, anticorps CASP8 and FADD-like apoptosis regulator a, anticorps CASP8 and FADD like apoptosis regulator, anticorps CASP8 and FADD like apoptosis regulator S homeolog, anticorps CASP8 and FADD-like apoptosis regulator, anticorps cflara, anticorps CFLAR, anticorps cflar, anticorps cflar.S, anticorps Cflar
- Sujet
- FLIP interacts with the adaptor protein FADD, and with Caspase-8 (FLICE) and Caspase-10 (FLICE2) to inhibit apoptosis induced by death receptors including CD95, DR3, TRAIL-R and TNFR1. FLICE inhibitory proteins were initially identified in virus and human and were accordingly designated as v-FLIPs and c-FLIPs. Four spice variants of c-FLIP have been identified and are classified as FLIP alpha, beta, delta and gamma. AHP1591 recognizes human and murine delta and gamma variants but not the alpha or beta, variants. FLIP is widely expressed in human tissues and a diverse range of cell lines.Synonyms: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP
- ID gène
- 8837
- NCBI Accession
- NP_001120655
- UniProt
- O15519
- Pathways
- Apoptose, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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