SLC2A4
Reactivité: Humain, Souris, Rat
WB, ELISA, IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Peptide ELISA: Limit Dilution: 1/16000. Western blot: 0.2-0.5 μg/mL. This antibody detects a band of approx. 45 kDa in Mouse and RatHeart lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.5 mg/mL
Buffer
Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Antigène
GLUT4 (SLC2A4)
(Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4))
anticorps GLUT4, anticorps Glut-4, anticorps Glut4, anticorps glut4, anticorps slc2a4, anticorps SLC2A4, anticorps solute carrier family 2 member 4, anticorps solute carrier family 2 (facilitated glucose transporter), member 4, anticorps solute carrier family 2 (facilitated glucose transporter), member 4 L homeolog, anticorps SLC2A4, anticorps Slc2a4, anticorps GLUT4, anticorps slc2a4.L
Sujet
The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.Synonyms: GLUT-4, Glucose transporter 4, Glucose transporter type 4 insulin-responsive, Solute carrier family 2 facilitated glucose transporter member 4