ITGB1 anticorps
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- Antigène Voir toutes ITGB1 Anticorps
- ITGB1 (Integrin beta 1 (ITGB1))
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Reactivité
- Souris
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Hôte
- Rat
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ITGB1 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)
- Marque
- BD Pharmingen™
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Mouse endothelial cell line
- Clone
- 9EG7
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product ITGB1 Anticorps primaire
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- Indications d'application
- For IHC, we recommend the use of purified 9EG7 mAb in our special formulation for immunohistochemistry.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4° C.
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A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co-stimulatory molecules." dans: European journal of immunology, Vol. 28, Issue 3, pp. 926-35, (1998) (PubMed).
: "Adhesion of lymphoma cells to fibronectin: differential use of alpha 4 beta 1 and alpha 5 beta 1 integrins and stimulation by the 9EG7 mAb against the murine beta 1 integrin subunit." dans: Cell adhesion and communication, Vol. 3, Issue 4, pp. 327-36, (1996) (PubMed).
: "A role in migration for the alpha V beta 1 integrin expressed on oligodendrocyte precursors." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 22, pp. 7240-52, (1996) (PubMed).
: "Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 7, pp. 2916-23, (1996) (PubMed).
: "Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion." dans: The Journal of biological chemistry, Vol. 269, Issue 31, pp. 19859-67, (1994) (PubMed).
: "The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly." dans: The Journal of biological chemistry, Vol. 269, Issue 16, pp. 12263-8, (1994) (PubMed).
: "Adhesion receptors of the immune system." dans: Nature, Vol. 346, Issue 6283, pp. 425-34, (1990) (PubMed).
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A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co-stimulatory molecules." dans: European journal of immunology, Vol. 28, Issue 3, pp. 926-35, (1998) (PubMed).
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- Antigène
- ITGB1 (Integrin beta 1 (ITGB1))
- Autre désignation
- CD29 (ITGB1 Produits)
- Synonymes
- anticorps CD29, anticorps FNRB, anticorps GPIIA, anticorps MDF2, anticorps MSK12, anticorps VLA-BETA, anticorps VLAB, anticorps 4633401G24Rik, anticorps AA409975, anticorps AA960159, anticorps ENSMUSG00000051907, anticorps Fnrb, anticorps Gm9863, anticorps gpIIa, anticorps cd29, anticorps fnrb, anticorps gpiia, anticorps itgb1, anticorps mdf2, anticorps msk12, anticorps vla-beta, anticorps vlab, anticorps itgb1-a, anticorps itgb1-b, anticorps integrin subunit beta 1, anticorps integrin beta 1 (fibronectin receptor beta), anticorps integrin subunit beta 1 S homeolog, anticorps integrin beta 1, anticorps integrin subunit beta 1 L homeolog, anticorps ITGB1, anticorps Itgb1, anticorps itgb1.S, anticorps LOC100009173, anticorps itgb1.L
- Sujet
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The 9EG7 antibody reacts with the 130-kDa integrin beta1 chain (CD29). CD29 is expressed on the cell surface as a heterodimer with one of the distinct integrin alpha chains. With alpha1 through alpha6 (CD49a through CD49f), it forms the VLA-1 through VLA-6 complexes, respectively, and with alphav (CD51), it forms alphavbeta1 integrin. It also associates with the integrin alpha7 alpha8 and alpha9 chains in non-lymphoid tissues. As a result, CD29 has a broad tissue distribution, including lymphocytes, endothelia, smooth muscle, and epithelia. 9EG7 mAb has been shown to inhibit both the alpha6beta1-mediated binding of lymphocytes to endothelial cells and the adhesion mediated by activated, but not unactivated, alpha4beta1-integrin. The source of the immunogen was mouse lymph node-derived endothelial cell line TME.
Synonyms: Integrin beta1 chain - Pathways
- Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome
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