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anti-Human NRF2 Anticorps:
anti-Mouse (Murine) NRF2 Anticorps:
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Human Polyclonal NRF2 Primary Antibody pour IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. dans Free radical biology & medicine 2012
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Human Polyclonal NRF2 Primary Antibody pour IF (p), IHC (p) - ABIN737271
Wang, Fang, Huang, Chen, Fan, Wang: The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats. dans Environmental toxicology and pharmacology 2013
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Human Polyclonal NRF2 Primary Antibody pour IHC, IHC (p) - ABIN4340688
Suchocki, Misiewicz-Krzemińska, Skupińska, Niedźwiecka, Lubelska, Fijałek, Kasprzycka-Guttman: Selenitetriglicerydes affect CYP1A1 and QR activity by involvement of reactive oxygen species and Nrf2 transcription factor. dans Pharmacological reports : PR 2010
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Human Polyclonal NRF2 Primary Antibody pour ChIP, ICC - ABIN442777
Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. dans Molecular cell 2013
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Human Polyclonal NRF2 Primary Antibody pour ICC, IHC (p) - ABIN3044196
Wang, Du, Duan, Guo, Sun, Liu: Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation. dans World journal of gastroenterology : WJG 2013
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Human Polyclonal NRF2 Primary Antibody pour IHC (p), WB - ABIN3043888
Li, Xie, Chen, Wang, Yu: Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1. dans The Journal of surgical research 2015
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Human Polyclonal NRF2 Primary Antibody pour IHC, ELISA - ABIN1584873
Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. dans Pharmacological research : the official journal of the Italian Pharmacological Society 2012
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Human Monoclonal NRF2 Primary Antibody pour IHC, ELISA - ABIN1724931
Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. dans Physiological genomics 2012
Human Monoclonal NRF2 Primary Antibody pour IF, ELISA - ABIN518315
Lindl, Jordan-Sciutto: Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue. dans Methods in molecular biology (Clifton, N.J.) 2008
These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.
we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (Montrer AKT1 Anticorps) and JNK (Montrer MAPK8 Anticorps)/Nrf2/NQO1 (Montrer NQO1 Anticorps) pathway.
Bach1 (Montrer BACH1 Anticorps) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (Montrer BACH1 Anticorps) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf (Montrer NRF1 Anticorps) genes varies temporally throughout development and nrf (Montrer NRF1 Anticorps) genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b (Montrer GABPb Anticorps).
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (Montrer HMOX1 Anticorps) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (Montrer HMOX1 Anticorps) gene expression in aortic endothelial cells by advanced glycation end products
Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
We demonstrated that one Brazil nut daily for 3 months was able to increase Nfr2 mRNA expression and to reduce NF-kappaB (Montrer NFKB1 Anticorps) mRNA expression in hemodialysis patients.
Punicalagin protects HepG2 cells from lipotoxicity induced by free fatty acids through activating Nrf2 (Montrer GABPA Anticorps)/Keap1 (Montrer KEAP1 Anticorps) pathway.
NRF2 (Montrer GABPA Anticorps) as a key regulator of multiple myeloma survival in treatment naive and proteasome inhibitors treated cells.
These results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 (Montrer GABPA Anticorps) response to arsenic and cadmium.
Authors further found that over expression of D117E and Q141H variants of NFE2L2 reduced target genes expression of Glutathione S-transferase Pi 1 (GSTP1 (Montrer GSTP1 Anticorps)), Glutathione S-transferase Mu 1 (GSTM1 (Montrer GSTM1 Anticorps)), and Heme oxygenase 1 (HO-1 (Montrer HMOX1 Anticorps)) genes. NFE2L2 D117E and Q141H impaired activation of ARE-driven transcriptional activity.
Data suggest that Keap1 (Montrer KEAP1 Anticorps), rather than Nrf2 (Montrer GABPA Anticorps), is critical for the recruitment of iASPP (Montrer PPP1R13L Anticorps) into the Keap1 (Montrer KEAP1 Anticorps)-Nrf2 (Montrer GABPA Anticorps) complex
Supplementation with sulforaphane-containing broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model via Nrf2 (Montrer GABPA Anticorps) activation.
Authors found a significant correlation between NRF2 (Montrer GABPA Anticorps) and IL-11 (Montrer IL11 Anticorps) status in breast cancer patients. Based on a recent report demonstrating that IL-11 (Montrer IL11 Anticorps) is induced downstream of NRF2 (Montrer GABPA Anticorps), authors examined the significance of IL-11 (Montrer IL11 Anticorps) in NRF2 (Montrer GABPA Anticorps)-driven tumorigenesis with a newly established NRF2 (Montrer GABPA Anticorps) addiction cancer model.
The modification of NRF2 (Montrer GABPA Anticorps) or KEAP1 (Montrer KEAP1 Anticorps) expression in non-small cell lung cancer cell lines disrupted downstream gene expression and cell sensitivity to platinum-based drugs.
Our findings suggest a novel mechanism by which CCE procyanidins can promote proteasome-independent degradation of nuclear Nrf2 (Montrer GABPA Anticorps) through IGF-1R (Montrer IGF1R Anticorps) phosphorylation and cysteine protease (Montrer CTSB Anticorps) activation.
Data indicate that promyelocytic leukemia protein (Montrer PML Anticorps) knockout (Pml (Montrer PML Anticorps)-/-) animals fail to properly activate oxidative stress-responsive p53 (Montrer TP53 Anticorps) targets, whereas the NRF2 response is amplified and accelerated.
Impaired Nrf2-dependent redox homeostasis is an important mechanism that promotes cell death downstream of IFN-I and RIP3 (Montrer MPRIP Anticorps) signaling in S. Typhimurium-infected macrophages.
Data show that mice that lack nuclear factor (erythroid-derived 2)-like 2 (NRF2) are more susceptible to burn-induced intestinal injury and have more systemic inflammation and a lower survival rate.
Increased Nrf2 signaling suppresses hypothalamic oxidative stress.
The major reactive oxygen species (ROS (Montrer ROS1 Anticorps)) source in brain, NADPH oxidase (Montrer NOX1 Anticorps) subunit 4 increased in hypoxia but not in hyperoxia, whereas neither affected nuclear factor (erythroid-derived 2)-like 2, a transcription factor that regulates the expression of antioxidant proteins
genetic disruption of Nrf2 promotes the transition from iron accumulation (siderosis) to liver injury in Hfe (Montrer HFE Anticorps)(-/-) mice, representing the first demonstration of spontaneous hepatic fibrosis in the long term in a mouse model of hereditary hemochromatosis (Montrer HFE Anticorps) displaying mildly elevated liver iron
Findings suggest that nuclear factor erythroid 2-related factor 2 deficiency aggravates denervation-induced oxidative stress, but does not affect the alterations in mitochondrial morphology proteins and the loss of skeletal muscle mass.
Data suggest that activation of Nrf2 can be effected by dietary factors via epigenetic mechanisms; here, in studies using epidermal cells treated with carcinogen to induce neoplastic transformation, ursolic acid (an anticarcinogenic, triterpenoid dietary supplement) prevents neoplastic transformation and reduces expression of epigenetic modifying enzymes including DNA methyltransferases and histone deacetylases.
Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis.
Study revealed that dysfunctional oxidative stress-activated Nrf2 signaling and autophagy are probably responsible for diabetes mellitus-induced defects in the placental development of mice. The mechanism seemed to be through the interference with differentiation-related gene expression in trophoblast cells.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2