Aperçu des produits pour PDK2 (PDK2) Kits ELISA

Full name:
Pyruvate Dehydrogenase Kinase, Isozyme 2 Kits ELISA (PDK2)
Chez www.anticorps-enligne.fr sont 2 Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) Kits ELISA de 2 de différents fournisseurs disponibles. De plus, nous expédions PDK2 Anticorps (144) et PDK2 Protéines (7) et beaucoup plus de produits pour cette protéine. Un total de 161 PDK2 produits sont actuellement listés.
Synonymes:
3j828, MGC52849, MGC132353, PDHK2, Pdk, PDK2, PDKII, zgc:56209
list all ELISA KIts Gène GeneID UniProt
PDK2 18604 Q9JK42
Humain PDK2 PDK2 5164 Q15119
Rat PDK2 PDK2 81530 Q64536

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PDK2 (PDK2) Kits ELISA par réactivité

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Plus Kits ELISA pour PDK2 partenaires d'interaction

Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) interaction partners

  1. The current study reports that increasing hepatic PDC (Montrer PDC Kits ELISA) activity by inhibition of PDK2 ameliorates hepatic steatosis and insulin (Montrer INS Kits ELISA) sensitivity by regulating TCA cycle anaplerosis and ketogenesis. The findings suggest PDK2 is a potential therapeutic target for nonalcoholic fatty liver disease.

  2. PDK2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.

  3. Double-knockout mice with global deletion of PDK2 and PDK4 (Montrer PDK4 Kits ELISA), which results in constitutively activated pyruvate dehydrogenase (Montrer PDP Kits ELISA), preferentially oxidize glucose in muscle.

  4. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2.

  5. The Pdk4 (Montrer PDK4 Kits ELISA) gene knockdown led to better glucose tolerance than the Pdk2 gene knockdown.

  6. loss of both Pdk2 and Pdk4 (Montrer PDK4 Kits ELISA) attenuated HSC (Montrer FUT1 Kits ELISA) quiescence, glycolysis, and transplantation capacity.

  7. Results established that wild-type p53 (Montrer TP53 Kits ELISA) prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 (Montrer TP53 Kits ELISA) suppresses tumorigenesis acting at the level of cancer cell metabolism.

  8. PDK2 activity is essential, even at rest, in regulation of carbohydrate oxidation and production of reducing equivalents for the electron transport chain.

  9. mitochondrial ND2 (Montrer MT-ND2 Kits ELISA) mutation contributes to HIF1alpha (Montrer HIF1A Kits ELISA) accumulation via increased ROS (Montrer ROS1 Kits ELISA) production, up-regulation of PDK2, attenuating PDH (Montrer PDP Kits ELISA) activity, thereby increasing pyruvate, resulting in HIF1alpha (Montrer HIF1A Kits ELISA) stabilization

Human Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) interaction partners

  1. The data demonstrate potential roles of PDK2 and ABCG2 (Montrer ABCG2 Kits ELISA) polymorphisms in the metabolic phenotypes of Tibetan gout patients.

  2. High glycolysis and PDK2 overexpression are closely linked to cisplatin resistance in head and neck cancer cells, which can be reversed by PDK2 nhibition.

  3. both PDK 1 (Montrer PDK1 Kits ELISA) and 2 isoforms are overexpressed in cutaneous melanoma compared to nevi, this expression being associated with the expression of the mTOR (Montrer FRAP1 Kits ELISA) pathway effectors and independent of the BRAF (Montrer BRAF Kits ELISA) mutational status

  4. The findings of the present study reveal a novel survival pathway that functionally couples the unique glycolytic phenotype in cancer cells to hypoxia resistance via a PDK2-dependent mechanism that switches Bnip3 (Montrer BNIP3 Kits ELISA) from cell death to survival.

  5. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2.

  6. Germline mutations in PKD2 (Montrer PKD2 Kits ELISA) gene is associated with autosomal-dominant polycystic kidney disease.

  7. we for the first time demonstrated that a low-nutrient condition drives cancer cells to utilize glycolysis to produce ATP, and this increases the Warburg effect through a novel mechanism involving ROS (Montrer ROS1 Kits ELISA)/AMPK (Montrer PRKAA1 Kits ELISA)-dependent activation of PDK.

  8. Mitochondrial activation by inhibition of PDKII suppresses HIF1a (Montrer HIF1A Kits ELISA) signaling and angiogenesis in cancer.

  9. Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.

  10. Results established that wild-type p53 (Montrer TP53 Kits ELISA) prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 (Montrer TP53 Kits ELISA) suppresses tumorigenesis acting at the level of cancer cell metabolism.

PDK2 profil antigène

Antigen Summary

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with PDK2

  • pyruvate dehydrogenase kinase, isozyme 4 (pdk4) Elisa Kit
  • pyruvate dehydrogenase kinase, isoenzyme 2 (pdk2) Elisa Kit
  • pyruvate dehydrogenase kinase, isozyme 2 (PDK2) Elisa Kit
  • pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2) Elisa Kit
  • pyruvate dehydrogenase kinase, isozyme 2 (Pdk2) Elisa Kit
  • 3j828 Elisa Kit
  • MGC52849 Elisa Kit
  • MGC132353 Elisa Kit
  • PDHK2 Elisa Kit
  • Pdk Elisa Kit
  • PDK2 Elisa Kit
  • PDKII Elisa Kit
  • zgc:56209 Elisa Kit

Protein level used designations for PDK2

pyruvate dehydrogenase kinase 2 , pyruvate dehydrogenase kinase, isoenzyme 2 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial , pyruvate dehydrogenase kinase, isozyme 2 , PDH kinase 2 , pyruvate dehydrogenase 2 , pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial , PDK P45 , pyruvate dehydrogenase kinase 2 subunit p45 (PDK2)

GENE ID SPECIES
379789 Xenopus laevis
393971 Danio rerio
468402 Pan troglodytes
18604 Mus musculus
5164 Homo sapiens
81530 Rattus norvegicus
524075 Bos taurus
100516037 Sus scrofa
491075 Canis lupus familiaris
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