ABL1 Produits
(C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
Catégories
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9\;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008].
antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.
Catégories ABL1 en vedette
ABL1 Anticorps
High quality antibodies with extensive validation data.
ABL1 Kits ELISA
Reliable ELISA kits for a wide range of species.
ABL1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
ABL1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
N° du produit
ABIN3020872
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), DB
Validations
- (1)
- (4)
N° du produit
ABIN6241067
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (1)
- (4)
N° du produit
ABIN6256686
Quantité
100 μL
Fiche technique
Fiche technique
ABL1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
N° du produit
ABIN6730567
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6975039
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380761
Quantité
2 x 96 tests
Fiche technique
Fiche technique
ABL1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
N° du produit
ABIN5570741
Quantité
5 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
N° du produit
ABIN5569840
Quantité
5 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
N° du produit
ABIN5569841
Quantité
5 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits ABL1
: "Defining the target and the effect of imatinib on the filarial c-Abl homologue." dans: PLoS neglected tropical diseases, Vol. 11, Issue 7, pp. e0005690, (2017) (PubMed).: "A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy." dans: The Analyst, Vol. 140, Issue 4, pp. 1207-14, (2015) (PubMed).
: "Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease." dans: Redox biology, Vol. 2, pp. 82-90, (2015) (PubMed).
: "Altered expression of c-Abl in patients with epilepsy and in a rat model." dans: Synapse (New York, N.Y.), Vol. 68, Issue 7, pp. 306-16, (2014) (PubMed).
: "MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction." dans: Cancer discovery, Vol. 4, Issue 2, pp. 200-15, (2014) (PubMed).
: "Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway." dans: Scientific reports, Vol. 4, pp. 6527, (2014) (PubMed).
: "Non-receptor-tyrosine kinases integrate fast glucocorticoid signaling in hippocampal neurons." dans: The Journal of biological chemistry, Vol. 288, Issue 33, pp. 23725-39, (2013) (PubMed).
: "Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors." dans: PLoS ONE, Vol. 7, Issue 10, pp. e45964, (2012) (PubMed).
: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).
: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." dans: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, (2006) (PubMed).
Synonymes et noms alternatifs relatifs à ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), c-abl oncogene 1, non-receptor tyrosine kinase (Abl1), ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), Tyrosine-protein kinase abl-1 (abl-1), c-abl oncogene 1, non-receptor tyrosine kinase (abl1), ABL, Abl, AI325092, bcr/abl, c-ABL, c-Abl, E430008G22Rik, JTK7, p150, v-ablProtein level used designations for ABL1
- Abelson tyrosine-protein kinase 1
- bcr/c-abl oncogene protein
- c-abl oncogene 1, receptor tyrosine kinase
- proto-oncogene c-Abl
- proto-oncogene tyrosine-protein kinase ABL1
- tyrosine-protein kinase ABL1
- v-abl Abelson murine leukemia viral oncogene homolog 1
- Abelson murine leukemia oncogene
- abelson murine leukemia viral oncogene homolog 1
- p150
- v-abl Abelson murine leukemia oncogene 1
- Abelson murine leukemia viral (v-abl) oncogene homolog 1
- v-abl Abelson murine leukemia viral oncogene 1
Vous êtes ici:
