ABL1 Protein (AA 4-194, partial) (GST tag)

N° du produit ABIN1047855

Détail du produit

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Type de proteíne: Recombinant

Attributs du protein: AA 4-194, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ABL1 protéine est marqué à la GST tag.

Application: ELISA

Séquence: ICLKLVGCKS KKGLSSSSSC YLEEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP NLFVALYDFV ASGDNTLSIT KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS NYITPVNSLE KHSWYHGPVS RNAAEYLLSS GINGSFLVRE SESSPGQRSI SLRYEGRVYH YRINTASDGK LYVSSESRFN T

Attributs du produit: Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.

Pureté: 90 %

Information d'application

Commentaires:

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: 0.2-2 mg/mL

Buffer: Tris-based buffer, 50 % glycerol

Conseil sur la manipulation: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week

Stock: -20 °C

Stockage commentaire: Store at -20 °C for extended storage, conserve at -20 °C or -80 °C

Référence

Fainstein, Einat, Gokkel, Marcelle, Croce, Gale, Canaani: "Nucleotide sequence analysis of human abl and bcr-abl cDNAs." dans: Oncogene, Vol. 4, Issue 12, pp. 1477-81, (1990) (PubMed).

Shtivelman, Lifshitz, Gale, Roe, Canaani: "Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene." dans: Cell, Vol. 47, Issue 2, pp. 277-84, (1986) (PubMed).

Détail du antigène

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Autre désignation: Tyrosine-Protein Kinase ABL1 Protein (ABL1 Produits)

Synonymes: ABL Protein, JTK7 Protein, bcr/abl Protein, c-ABL Protein, p150 Protein, v-abl Protein, AI325092 Protein, Abl Protein, E430008G22Rik Protein, c-Abl Protein, ABL proto-oncogene 1, non-receptor tyrosine kinase Protein, c-abl oncogene 1, non-receptor tyrosine kinase Protein, Tyrosine-protein kinase abl-1 Protein, ABL1 Protein, Abl1 Protein, abl-1 Protein, abl1 Protein

Sujet: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Poids moléculaire: 48.5 kD

UniProt: P00520

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism