AF4/FMR2 Family, Member 2 Protéines (AFF2)

AFF2 encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. De plus, nous expédions AF4/FMR2 Family, Member 2 Anticorps (52) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
AFF2 2334 P51816
AFF2 14266 O55112
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Top AF4/FMR2 Family, Member 2 Protéines sur anticorps-enligne.fr

Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$331.20
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AFF2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour AF4/FMR2 Family, Member 2 (AFF2) partenaires d'interaction

Human AF4/FMR2 Family, Member 2 (AFF2) interaction partners

  1. Partial AFF2 microduplication in a patient with auditory processing disorder, emotional impairment and macrosomia.

  2. FMR2 is an upstream regulator of FOS and JUN (Montrer JUN Protéines), and further link deregulation of the immediate early (Montrer JUN Protéines) response genes to the pathology of ID- and FRAXE-associated ID in particular.

  3. 2.5% of males Autism spectrum disorder patients had missense mutations in AFF2 at highly conserved evolutionary sites.

  4. A report of novel deletions involving AFF2 provide evidence for a new mutational spectrum, microdeletions, that are responsible for Fragile X (Montrer FMR1 Protéines) E in a small subset of patients.

  5. overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles.

  6. CGG/GCC (Montrer GUCY2C Protéines) repeat polymorphism at the FMR1 (Montrer FMR1 Protéines) and FMR2 loci observed in this study demonstrated a racial and ethnic variation among the populations in India.

  7. FMR1 (Montrer FMR1 Protéines) transcripts were detected in foreskin and male fetal lung fibroblasts, while FMR2 transcripts were not. However, both FMR1 (Montrer FMR1 Protéines) and FMR2 were found to replicate late in S phase (approximately 6 h into the S phase of normal human fibroblasts).

Mouse (Murine) AF4/FMR2 Family, Member 2 (AFF2) interaction partners

  1. Overlapping expression of Af9 (Montrer MLLT3 Protéines) with Af4/Aff1 and Fmr2/Aff2, two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl (Montrer MLLT1 Protéines).

Profil protéine AF4/FMR2 Family, Member 2 (AFF2)

Profil protéine

This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with AFF2

  • AF4/FMR2 family member 2 (AFF2)
  • AF4/FMR2 family, member 2 (Aff2)
  • Fmr2 Protéine
  • FMR2P Protéine
  • FRAXE Protéine
  • MRX2 Protéine
  • Ox19 Protéine
  • Oxh Protéine

Protein level used designations for AFF2

AF4/FMR2 family member 2 , fragile X E mental retardation syndrome protein , fragile X mental retardation 2 protein , protein FMR-2 , Ox19 homolog , fragile X mental retardation 2 homolog , fragile X mental retardation protein 2 homolog , fragile X mental retardation 2

GENE ID SPECIES
100434131 Pongo abelii
422394 Gallus gallus
2334 Homo sapiens
522215 Bos taurus
14266 Mus musculus
450122 Pan troglodytes
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