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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. De plus, nous expédions ATG4B Protéines (13) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal ATG4B Primary Antibody pour IF, IHC (p) - ABIN1882065
Pontén, Westermark: Properties of human malignant glioma cells in vitro. dans Medical biology 1978
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Human Polyclonal ATG4B Primary Antibody pour WB - ABIN1881082
Kabeya, Mizushima, Yamamoto, Oshitani-Okamoto, Ohsumi, Yoshimori: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. dans Journal of cell science 2004
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Human Polyclonal ATG4B Primary Antibody pour IHC (p), WB - ABIN388494
Baehrecke: Autophagy: dual roles in life and death? dans Nature reviews. Molecular cell biology 2005
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These results support the conclusion that CML24 affects autophagy progression through interactions with ATG4.
AtATG4a is catalytically more active and has broad AtATG8 substrate specificity compared with AtATG4b. [ATG4b]
ATG4B contains a C-terminal LIR (Montrer CD300C Anticorps) motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 (Montrer GABARAPL2 Anticorps)
O-GlcNAcylation of ATG4B regulates autophagy activation by increasing its proteolytic activity under metabolic stress condition
these results demonstrate a novel association of ATG4B positive expression with HER2 (Montrer ERBB2 Anticorps) positive breast cancers
Knockdown of ATG4B had only a minor effect on AMPK (Montrer PRKAA1 Anticorps) activation and G1 phase arrest in liver kinase B1 (Montrer STK11 Anticorps)-deficient or AMPK (Montrer PRKAA1 Anticorps)-inhibited cancer cells.
Our work describes an MST4 (Montrer MST4 Anticorps)-ATG4B signaling axis that influences glioblastoma autophagy and malignancy
Data show that ULK1 (Montrer ULK1 Anticorps), a protein kinase (Montrer CDK7 Anticorps) activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316.
Reporter assay showed that HSF1 (Montrer HSF1 Anticorps) increased the transcriptional activity of ATG4B gene promoter, and chromatin immunoprecipitation assay verified that HSF1 (Montrer HSF1 Anticorps) bound to the site (-1429 to -1417) in ATG4B gene promoter region.
The structure and regulatory machinery of Atg4b [review]
MIRlet-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of pre-eclampsia.
The results have interesting implications that SLC27A4 (Montrer SLC27A4 Anticorps)/ATG4B complex might be conducive to the occurrence of autophagy in human cancer cells, which is meaningful investigations toward the aim of developing autophagy-targeting drugs and have significant values in clinical application.
ATG4B contains a C-terminal LIR (Montrer CD300C Anticorps) motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 (Montrer MAP1LC3B Anticorps)
miR (Montrer MLXIP Anticorps)-34a might regulate the autophagic activity and can cause injury in ischemia reperfusion injured renal tubular epithelial cells (RTEC) via targeting Atg4B. Atg4B knockdown inhibited autophagy in RTECs.
the ATG4B protease and autophagy play a crucial role protecting epithelial cells against bleomycin-induced stress and apoptosis
REDD1 (Montrer DDIT4 Anticorps)/TXNIP (Montrer TXNIP Anticorps) complex expression is sufficient to induce reactive oxygen species, suppress ATG4B activity and activate autophagy.
these findings demonstrate a role for Ser (Montrer SIGLEC1 Anticorps)-383 and Ser (Montrer SIGLEC1 Anticorps)-392 phosphorylation of ATG4B in control of autophagy.
mTOR (Montrer FRAP1 Anticorps) inhibition alleviates Huntington's disease progression by inducing Atg4b-dependent autophagic flux.
An autophagy-related gene, Atg4b, is identified as a de novo target gene of C/EBP BETA (Montrer CEBPB Anticorps) and is shown to play an important role in 3T3-L1 adipocyte differentiation.
the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 (Montrer MAP1LC3A Anticorps) processing and autophagy.
The Atg4b participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane.
Genetic inactivation of mouse Atg4b resulted in amorphous globular bodies in the neuropil of the deep cerebellar nuclei and adjacent vestibular nuclei and a mild but measurable impairment of motor performance on the Rotarod.
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ATG4 autophagy related 4 homolog B
, cysteine protease ATG4B
, autophagy 4b variant 1Cysteine protease ATG4B
, autophagy 4b variant 3
, cysteine protease ATG4b
, APG4 autophagy 4 homolog B
, autophagy-related protein 4 homolog B
, autophagy-related cysteine endopeptidase 2B
, AUT-like 1 cysteine endopeptidase
, autophagy-related cysteine endopeptidase 1
, APG4 (ATG4) autophagy-related homolog B
, AUT-like 1, cysteine endopeptidase
, autophagin 1
, autophagy-related 4B
, cysteine protease involved in autophagy APG4-B
, autophagy related 4 homolog B
, autophagy related 4-like protein B