anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Anticorps

The membrane-associated protein encoded by ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. De plus, nous expédions ABCA4 Protéines (11) et ABCA4 Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
ABCA4 24 P78363
ABCA4 11304 O35600
ABCA4 310836  
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Top anti-ABCA4 Anticorps sur anticorps-enligne.fr

Showing 10 out of 68 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Souris Lapin Inconjugué WB Western blot analysis of ABCA4 expression in rat eye extract ( Lane 1) and mouse eye extract ( Lane 2). ABCA4 at 256KD was detected using rabbit anti-ABCA4 Antigen Affinity purified polyclonal antibody (Catalog #) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Chien Lapin Inconjugué WB Western blot analysis of ABCA4 expression in HEK293T (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Chèvre Inconjugué ELISA   100 μg Connectez-vous pour afficher 6 to 7 Days
$291.53
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of ABCA4 using HT29 whole cell lysates 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Souris Lapin Inconjugué WB Anti-ABCA4 antibody, Western blotting All lanes: Anti ABCA4  at 0.5ug/ml WB: Mouse Brain Tissue Lysate at 50ug Predicted bind size: 256KD Observed bind size: 256KD 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué WB Anti-ABCA4 antibody, Western blotting WB: U87 Cell Lysate 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p) Human Brain, Cortex 100 μL Connectez-vous pour afficher 11 to 14 Days
$375.83
Détails
Boeuf (Vache) Souris Inconjugué IHC (fro), IHC, WB Immunohistochemistry: ABCA4 Antibody (3F4) [NBP1-30032] - staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$488.73
Détails
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Recombinant ABCA4, Human. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Connectez-vous pour afficher 13 to 16 Days
$350.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cells, using ABCA4 antibody. 100 μL Connectez-vous pour afficher 16 Days
$366.77
Détails

anti-ABCA4 Anticorps mieux référencés

  1. Cow (Bovine) Monoclonal ABCA4 Primary Antibody pour IHC (fro), IHC - ABIN447448 : Wiszniewski, Zaremba, Yatsenko, Jamrich, Wensel, Lewis, Lupski: ABCA4 mutations causing mislocalization are found frequently in patients with severe retinal dystrophies. dans Human molecular genetics 2005 (PubMed)
    Show all 2 Pubmed References

  2. Polyclonal ABCA4 Primary Antibody pour ELISA - ABIN539866 : Allocca, Doria, Petrillo, Colella, Garcia-Hoyos, Gibbs, Kim, Maguire, Rex, Di Vicino, Cutillo, Sparrow, Williams, Bennett, Auricchio: Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. dans The Journal of clinical investigation 2008 (PubMed)

  3. Dog (Canine) Polyclonal ABCA4 Primary Antibody pour ELISA - ABIN408723 : Singh, Jalali, Hejtmancik, Kannabiran: Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy. dans American journal of ophthalmology 2006 (PubMed)

Plus d’anticorps contre ABCA4 partenaires d’interaction

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. neighboring deep-intronic ABCA4 variants (c.4539+2001G>A and c.4539+2028C>T) result in a retina-specific 345-nt pseudoexon insertion.

  2. Two intronic variants c.4773+3A>G and c.5461-10T>C, both predicted to affect splicing, are indeed disease-causing mutations due to skipping of exons 33, 34, 39 and 40 of ABCA4 gene. The experimental proof that ABCA4 mutations in STGD patients affect protein function is crucial for their inclusion to future clinical trials.

  3. The study broadens the spectrum of ABCA4 mutations with 60 likely pathogenic or pathogenic variants, all associated with Stargardt disease.

  4. Full-field electroretinography is a predictor of the natural course of ABCA4-associated retinal degeneration.

  5. Next-generation sequencing was effective for the molecular diagnosis of genetic diseases and specifically allowed a conclusive diagnosis in 80% (40/50) of the patients. As the ABCA4 gene does not show a preferential region for pathogenic variants, the diagnosis of Stargardt disease depends on broader analysis of the gene. The most common pathogenic variants in the ABCA4 gene described in the literature were also found.

  6. The results indicate that the p.Ala1773Val mutation in ABCA4 is associated with a severe retinal phenotype and thus, could be classified as null.

  7. The ROC phenotype is a unique classification of ABCA4 disease, which is caused by deleterious null biallelic ABCA4 mutations and is characterized by the rapid deterioration of retinal pigment epithelium and photoreceptor layers in the macula and significant choroidal thinning within the first 2 decades of life.

  8. ABCA4 midigenes reveal the full splice spectrum of all reported noncanonical splice site variants in Stargardt disease.

  9. These findings expand the mutation spectrums of ABCA4 and LRP5, and will be valuable for genetic counseling and development of therapeutic interventions for patients with Familial exudative vitreoretinopathy.

  10. Our analyses allowed us to classify novel variants in ABCA4 as being clearly loss-of-function mutations, and thus pathogenic variants.

  11. High prevalence of p.L541P, p.A1038V, and p.G1961E mutations of the ABCA4 gene has been established in patients with Stargardt disease by performing massive parallel sequencing of all coding regions of the ABCA4 gene.

  12. Two novel pathogenic ABCA4 mutations were identified in Chinese families with Stargardt disease.

  13. We report an unusual phenotype in a child with a clinical diagnosis of recessive Stargardt disease (STGD1) and two pathogenic variants in the ABCA4 gene.

  14. Studies indicate that variants in ABCA4 are associated with a wide variety of inherited retinal diseases.

  15. Segregation analysis is important in order to confirm the molecular diagnosis of patients with Stargardt disease, given the frequency of complex alleles in the ABCA4 gene. The various pathogenic variation combinations observed in this study were associated with different phenotypes.

  16. The histopathology of the retina in this patient with Stargardt disease displayed a highly degenerated fovea. In all retinal locations studied, cones were more severely affected than rods.

  17. Thirty six SNP including 9 previously not described, were identified in juvenile-onset blindness patients of south Asian decent.

  18. This study describes the functional effect and the molecular mechanism of the pathogenic ABCA4 variant c.5461-10T>C. The variant is functionally important as it leads to splicing defects and a reduced level of ABCA4 protein.

  19. study to determine the effect of 15 individual ABCA4 mutations on retinal disease severity; in the hemizygous state, 2/15 ABCA4 alleles retain preserved peripheral retinal function; 7/15 are associated with either preserved or only mildly abnormal retinal function, worse in older patients; 6/15 behave like null mutations

  20. The ABCA4 variant c.5461-10T-->C is located on a founder haplotype lacking other disease-causing rare sequence variants. In vitro studies revealed that it leads to mRNA exon skipping and ABCA4 protein truncation.

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. ABCA4 functions to recycle retinaldehyde released during proteolysis of rhodopsin in retinal pigment epithelium endolysosomes following daily phagocytosis of distal photoreceptor OS. ABCA4 deficiency in the retinal pigment epithelium may play a role in the pathogenesis of Recessive Stargardt disease 1.

  2. we show that the p.Asn965Ser ABCA4 variant expresses at half the level of WT ABCA4, partially mislocalizes to the endoplasmic reticulum (ER) of photoreceptors, is devoid of N-Ret-PE activated ATPase activity, and causes an increase in autofluorescence and the bisretinoid A2E associated with lipofuscin deposits in retinal pigment epithelial cells as found in Stargardt patients and Abca4 knockout mice.

  3. a comprehensive analysis using RNA-seq identified important roles of the acute stress response in the degenerating retina of Abca4-/-Rdh8-/- mice that are predisposed to retinal degeneration under light stress.

  4. Data indicate that knocking out the ATP-binding cassette transporter Abca4 gene correlated with an increase in all orange pigments.

  5. The viral oncoprotein HBx of Hepatitis B virus promotes the growth of hepatocellular carcinoma through cooperating with the cellular oncoprotein RMP.

  6. Despite pronounced lipofuscin accumulation in the retinal pigment epithelium of Abca4(-/-) mice, ERG and histology showed a slow age-related thinning of the photoreceptor layer similar to wild type controls up to 12 months.

  7. Abca4-deficient mice accumulate more of the toxic bisretinoid A2E than their ABCA4-competent counterparts which contribute to primary cone toxicity and may be associated with macular vision loss

  8. Mutations known to cause Stargardt disease decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activity of ABCA4

  9. The physiological role of Abca4 may include the translocation of 11-cis-retinal complexes across the disk membrane

  10. Upregulation of Abca4 in the liver is a tissue-specific compensatory consequence of the 'knock-out' of Abcc6 in mice.

  11. Abcr (-/-) mice exhibit progressive photoreceptor cell loss that is detectable at 8 months of age and that has worsened by 11 and 13 months of age.

  12. In 2-month-old Abca4-/- mice, A2E was found in the center of the retinal pigment epithelial tissue; with age, A2E increased across the tissue

  13. A long wavelength fluorescence emission intrinsic to abca4(-/-) retinal explants is shown to emanate from A2PE-H(2).

  14. Studies in mice suggest thet vitamin A supplementation should be avoided in patients with ABCA4 mutations or other retinal or macular dystrophies associated with lipofuscin accumulation in the retinal pigment epithelium.

  15. mice lacking both the ATP-binding cassette transporter 4 (Abca4) and enzyme retinol dehydrogenase 8 (Rdh8), proteins critical for all-trans-retinal clearance from photoreceptors, developed severe RPE/photoreceptor dystrophy at an early age

Cow (Bovine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. ABCA4 can transport N-11-cis-retinylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis-retinal and PE, from the lumen to the cytoplasmic leaflet of disk membranes.

  2. An 18 A-resolution structure of ABCA4 isolated from bovine rod outer segments was determined using electron microscopy and single-particle reconstruction

  3. partial dephosphorylation of native bovine ABCA4 led to reduction of both basal and stimulated ATPase activity. Thus, we present the first evidence that phosphorylation of ABCA4 can regulate its function

  4. results indicate that ATP binding cassette protein ABCA4 preferentially binds N-retinylidene-phosphatidylethanolamine with high affinity

Xenopus laevis ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) interaction partners

  1. Evolutionary alterations may increase the retinoid metabolite recycling capacity of ABCA4 and may improve dark adaptation.

ABCA4 profil antigène

Profil protéine

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Gene names and symbols associated with ABCA4

  • ATP binding cassette subfamily A member 4 (ABCA4) anticorps
  • ATP-binding cassette, sub-family A (ABC1), member 4 (Abca4) anticorps
  • ATP binding cassette subfamily A member 4 (Abca4) anticorps
  • ATP binding cassette subfamily A member 4 (abca4) anticorps
  • ATP binding cassette subfamily A member 4 L homeolog (abca4.L) anticorps
  • ATP-binding cassette, sub-family A (ABC1), member 4a (abca4a) anticorps
  • abc10 anticorps
  • abcr anticorps
  • armd2 anticorps
  • AW050280 anticorps
  • cord3 anticorps
  • D430003I15Rik anticorps
  • ffm anticorps
  • rmp anticorps
  • rp19 anticorps
  • stgd anticorps
  • stgd1 anticorps
  • zgc:91823 anticorps

Protein level used designations for ABCA4

ATP binding cassette transporter , ATP-binding cassette sub-family A member 4 , ATP-binding cassette transporter, retinal-specific , ATP-binding transporter, retina-specific , RIM ABC transporter , RIM protein , photoreceptor rim protein , retina-specific ABC transporter , retinal-specific ATP-binding cassette transporter , stargardt disease protein , ATP-binding cassette 10 , Rim protein , ATP-binding cassette, sub-family A (ABC1), member 4 , ATP-binding cassette, sub-family A member 4 , retinal-specific ATP transporter ABCA4 , retinal-specific ATP-binding cassette transporter-like , ATP-binding cassette, sub-family A, member 4 , retinal ABCA4 transporter , ATP-binding cassette, sub-family A (ABC1), member 4a

GENE ID SPECIES
24 Homo sapiens
11304 Mus musculus
281584 Bos taurus
310836 Rattus norvegicus
424490 Gallus gallus
444852 Canis lupus familiaris
496442 Xenopus (Silurana) tropicalis
745972 Pan troglodytes
100393904 Callithrix jacchus
100440877 Pongo abelii
100479076 Ailuropoda melanoleuca
497268 Xenopus laevis
100605850 Nomascus leucogenys
100725431 Cavia porcellus
100058746 Equus caballus
798993 Danio rerio
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