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S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. De plus, nous expédions AHCY Protéines (91) et AHCY Kits (24) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 116 products:
Human Monoclonal AHCY Primary Antibody pour ELISA, WB - ABIN513196
Fernandez-Sanchez, Gonatopoulos-Pournatzis, Preston, Lawlor, Cowling: S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation. dans Molecular and cellular biology 2009
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Human Polyclonal AHCY Primary Antibody pour IHC - ABIN965520
Yuan, Borchardt: Photoaffinity labeling of human placental S-adenosylhomocysteine hydrolase with [2-3H]8-azido-adenosine. dans The Journal of biological chemistry 1995
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Human Polyclonal AHCY Primary Antibody pour IF (p), IHC (p) - ABIN708611
Huang, Huan, Liu: A comparative proteomic analysis reveals important proteins for the fertilization and early embryonic development of the oyster Crassostrea gigas. dans Proteomics 2016
Human Monoclonal AHCY Primary Antibody pour ELISA, WB - ABIN559816
Kim, Kang, Lee, Lee, Yu, Kim, Lee: Identification of S100A8 and S100A9 as serological markers for colorectal cancer. dans Journal of proteome research 2009
Results uncover a H19 (Montrer NCKAP1 Anticorps)/SAHH circuit involving gene-methylation alterations by carcinogen BaP (Montrer PHB2 Anticorps).
We investigated previously assumed interaction with AHCY-like-1 protein (AHCYL1 (Montrer AHCYL1 Anticorps)), a paralog of AHCY. Indeed, significant interaction between both proteins exists. Additionally, silencing AHCYL1 (Montrer AHCYL1 Anticorps) leads to moderate inhibition of nuclear export of endogenous AHCY.
We have validated the vectors and confirmed self-association of AHCY, AHCYL1 (Montrer AHCYL1 Anticorps), and galectin-3 (Montrer LGALS3 Anticorps). In a high-throughput BiFC screen, we identified new AHCY interaction partners: galectin-3 (Montrer LGALS3 Anticorps) and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY-galectin-3 (Montrer LGALS3 Anticorps) interaction
In order to enable the development of small molecule AHCY inhibitors as targeted cancer therapeutics we developed an assay based on a RapidFire high-throughput mass spectrometry detection system, which allows the direct measurement of AHCY enzymatic activity.
SAH (Montrer ACSM3 Anticorps) hydrolase deficiency can remain asymptomatic in childhood, and the disorder can be associated with early onset hepatocellular carcinoma.
H19 (Montrer NCKAP1 Anticorps) knockdown activates SAHH, leading to increased DNMT3B (Montrer DNMT3B Anticorps)-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19 (Montrer NCKAP1 Anticorps)-Nctc1 locus.
S-adenosylhomocysteine hydrolase is regulated by lysine acetylation
SAHH can promote apoptosis, inhibit migration and adhesion of ESCC cells suggesting that it may be involved in carcinogenesis of the esophagus.
A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples.
Maintenance of ionizable active-site residues in catalytically suitable protonation states in closed forms of placental AHCY may be assisted by a water chain, stabilized by Asp182, that can import and export protons from and to the environment.
Ahcy was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions.
report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution.
report that Myc (Montrer MYC Anticorps) promotes upregulation of S-adenosyl homocysteine hydrolase.
AHCYL1 (Montrer AHCYL1 Anticorps) has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release
Hepatic steatosis and liver degeneration are prominent features of the ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy).
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, S-adenosyl-L-homocysteine hydrolase
, S-adenosyl-L-homocysteine hydrolase B
, adenosylhomocysteinase B
, adoHcyase B
, liver copper-binding protein