CD33 Molecule Protéines (CD33)

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. De plus, nous expédions CD33 Anticorps (530) et CD33 Kits (45) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
CD33 945 P20138
CD33 12489 Q63994
Rat CD33 CD33 690492  
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Showing 10 out of 34 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
HEK-293 Cells Humain His tag 50 μg 2 to 3 Days
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Human Cells Humain His tag,Fc Tag   50 μg 4 Days
Baculovirus infected Insect Cells Humain hIgG-His-tag 50 μg 13 to 16 Days
HEK-293 Cells Humain His tag 100 μg 2 to 3 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Human Cells Humain Fc Tag 100 μg 14 to 16 Days
Human Cells Souris His tag 50 μg 14 to 16 Days
Escherichia coli (E. coli) Souris His tag,T7 tag 100 μg 15 to 18 Days

CD33 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , , , ,
, , , , , , , ,
Mouse (Murine) , , ,
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CD33 Protéines mieux référencés

  1. Human CD33 Protein expressed in HEK-293 Cells - ABIN2713661 : Vyas, Schneider, Shatnyeva, Reiners, Tawadros, Kloess, Köhl, Hallek, Hansen, Pogge von Strandmann: Mono- and dual-targeting triplebodies activate natural killer cells and have anti-tumor activity in vitro and in vivo against chronic lymphocytic leukemia. dans Oncoimmunology 2016 (PubMed)

  2. Human CD33 Protein expressed in HEK-293 Cells - ABIN2713662 : Son, Diamond, Volpe, Aranow, Mackay, Santiago-Schwarz: Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression. dans Scientific reports 2017 (PubMed)

Plus protéines pour CD33 Molecule (CD33) partenaires d'interaction

Human CD33 Molecule (CD33) interaction partners

  1. In normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2.

  2. A potent CD3/CD33 bispecific FynomAb.

  3. Identify a subset of cord blood cells with CD33(+)CD34(+)CD38(-)CD45RA(-)CD90(+)CD49f(+) phenotype which are serially transplantable, but have diverse cell output profiles.

  4. Data show that the intensity level of CD33 protein (CD33) on the monocytes is directly related to the rs12459419 single nucleotide polymorphism (SNP) genotypes CC, CT and TT.

  5. These findings demonstrate that C1q and it's globular region interact with CD33 to activate its inhibitory motifs, while the collagen-like region does not. Whole C1q is required to crosslink CD33 and LAIR-1 and concurrently activate CD33/LAIR-1 inhibitory motifs.

  6. rs3865444 CD33 acts as a protective factor against late-onset Alzheimer's disease.

  7. Genetic variations in CD33 influence atrophy of specific Alzheimer's Disease-related brain structures; specifically the hippocampus and parahippocampal gyrus.

  8. The mean percentage of CD33-positivity of the myeloblast population was 80.5% in acute myeloid leukemia (AML), 81.8% in chronic myelomonocytic leukemia (CMML) and 75% in myelodysplastic syndromes (MDS).

  9. The 161533 TriKE induced superior NK cell cytotoxicity, degranulation, and cytokine production against CD33(+) HL-60 targets and increased NK survival and proliferation.

  10. High efficacy of CD33/CD3 TandAbs in various preclinical models of human AML.

  11. The use of CD33(+)CD11b(+)HLA-DR(-) cells as a predictive and prognostic biomarker.

  12. Data suggest that two SNPs in CD33 (rs3865444A, rs12459419T) that are protective of Alzheimer disease result in splice variants (CD33M, CD33m); CD33M localizes predominantly at cell surface in macrophage cell line; CD33m is primary intracellular form in neutrophils and a microglia cell line; intracellular CD33m accumulates in peroxisomes; activation of macrophages/neutrophils does not mobilize CD33m to cell surface.

  13. In cutaneous diffuse large b-cell lymphoma, a considerable proportion of CD33(+) myeloid-derived suppressor cells (MDSCs) with PD-L1 coexpression was admixed. Tumor cells expressed CD33 to variable degrees (2% to 60%). We propose that PD-L1(+) tumor cells and PD-L1(+) MDSCs shield the tumor against PD-1(+) tumor-infiltrating lymphocytes, consequently leading to inhibition and diminution of tumor-infiltrating lymphocytes.

  14. patients with the CC genotype for rs12459419 have a substantial response to Gemtuzumab Ozogamicin, making this a potential biomarker for the selection of patients with a likelihood of significant response to Gemtuzumab Ozogamicin.

  15. CD33-expressing microglia play a central role in the development of leukoencephalopathy in Nasu-Hakola disease brains

  16. There is substantial evidence that rs3865444 (CD33) function is related to AD pathways and pathology, but our data does not support an interaction with rs670139 (MS4A4E) that impacts AD risk.

  17. this study investigated the contribution of the immunoregulatory receptor CD33 to a uniquely human postreproductive disease, Alzheimer's dementia.

  18. the CD33 rs3865444 polymorphism is associated with Alzheimer's disease susceptibility in Chinese, European, and North American populations.

  19. CD33 and MS4A cluster variants are associated with LOAD susceptibility in East Asian populations.

  20. Among those with one or more APOE epsilon4 alleles, having one or more copies of the CD33 C (risk) allele may further increase the risk of cognitive decline

Mouse (Murine) CD33 Molecule (CD33) interaction partners

  1. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.

  2. CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis.

  3. mCD33 is expressed on myeloid precursors in the bone marrow

  4. SOCS3 inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 and its target protein CD33 are degraded concomitantly concomitantly.

Profil protéine CD33

Profil protéine

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

Gene names and symbols associated with CD33 Molecule Protéines (CD33)

  • CD33 molecule (CD33)
  • CD33 antigen (Cd33)
  • CD33 molecule (Cd33)
  • gp67 Protéine
  • p67 Protéine
  • Siglec-3 Protéine
  • SIGLEC3 Protéine

Protein level used designations for CD33 Molecule Protéines (CD33)

CD33 antigen (gp67) , gp67 , myeloid cell surface antigen CD33 , sialic acid binding Ig-like lectin 3 , sialic acid-binding Ig-like lectin 3

945 Homo sapiens
456242 Pan troglodytes
12489 Mus musculus
690492 Rattus norvegicus
102117580 Macaca fascicularis
719855 Macaca mulatta
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