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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction..
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Human CAPN1 Protein expressed in Human - ABIN411905
Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. dans Molecular and cellular biology 2010
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A total of 55 genes were differentially expressed in micro-calpain knockout mice.
calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2 (Montrer MMP2 Protéines)/TGF-beta1 (Montrer TGFB1 Protéines) pathway.
indicate that calpain-1 and calpain-2 (Montrer CAPN2 Protéines) play opposite roles in high increased intraocular pressure-induced ischemic injury
Results strengthen the roles of both calpain-1 and PHLPP1 in synaptic plasticity and learning and memory, and illustrate the complexities of the interactions between multiple pathways participating in synaptic plasticity.
Genetic ablation of calpain-1 ameliorates chronic pain behavior in sickle cell mice.
Our results indicate that calpain mediates cytokine-induced collagen-I synthesis and proliferation of ASMCs via the mTORC2 (Montrer CRTC2 Protéines)/Akt (Montrer AKT1 Protéines) signalling pathway, thereby regulating airway smooth muscle remodelling in asthma.
mutations in CAPN1 are an additional cause of ataxia in mammals, including humans.
Results indicate that calpain-1 and calpain-2 (Montrer CAPN2 Protéines) are differentially activated in hippocampus following seizure activity, with calpain-1 activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 (Montrer CAPN2 Protéines) is widely activated in pyramidal neurons of CA1 (Montrer CA1 Protéines) and CA3 (Montrer CA3 Protéines), and triggers neurodegenerative cascades.
Here we show the combined loss of glial glutamate (Montrer GRIN1 Protéines) transporters GLT1 (Montrer SLC1A2 Protéines) and GLAST (Montrer SLC1A3 Protéines) in spinal cord caused motor neuronal death and hindlimb paralysis.
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain 1