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Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.. De plus, nous expédions CAPN1 Anticorps (132) et CAPN1 Kits (11) et beaucoup plus de produits pour cette protéine.
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Human CAPN1 Protein expressed in Human - ABIN411905
Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. dans Molecular and cellular biology 2010
Show all 7 Pubmed References
Results strengthen the roles of both calpain-1 and PHLPP1 in synaptic plasticity and learning and memory, and illustrate the complexities of the interactions between multiple pathways participating in synaptic plasticity.
Genetic ablation of calpain-1 ameliorates chronic pain behavior in sickle cell mice.
Our results indicate that calpain mediates cytokine-induced collagen-I synthesis and proliferation of ASMCs via the mTORC2 (Montrer CRTC2 Protéines)/Akt (Montrer AKT1 Protéines) signalling pathway, thereby regulating airway smooth muscle remodelling in asthma.
mutations in CAPN1 are an additional cause of ataxia in mammals, including humans.
Results indicate that calpain-1 and calpain-2 (Montrer CAPN2 Protéines) are differentially activated in hippocampus following seizure activity, with calpain-1 activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 (Montrer CAPN2 Protéines) is widely activated in pyramidal neurons of CA1 (Montrer CA1 Protéines) and CA3 (Montrer CA3 Protéines), and triggers neurodegenerative cascades.
Here we show the combined loss of glial glutamate (Montrer GRIN1 Protéines) transporters GLT1 (Montrer SLC1A2 Protéines) and GLAST (Montrer SLC1A3 Protéines) in spinal cord caused motor neuronal death and hindlimb paralysis.
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
High calpain expression is associated with brain injury.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
calpains and calpastatin (Montrer CAST Protéines) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (Montrer TAGLN Protéines)-5HTT (Montrer SLC6A4 Protéines)(+) strain) PH, were investigated.
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain 1