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Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. De plus, nous expédions Cation Channel, Sperm Associated 4 Anticorps (26) et beaucoup plus de produits pour cette protéine.
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Catsper4 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer.
CATSPER4 is a cation-channel protein and has role in acrosome reaction and male fertility
Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions.
Data show that spinal cord injury doesn't significantly change the expression of CatSpers 4.
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials\; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
channel, sperm associated 4
, cation channel, sperm associated 4
, cation channel sperm-associated protein 4
, ion channel CatSper4
, cation channel of sperm 4